Prophylactic cryoprecipitate transfusion in patients undergoing scoliosis surgery: A randomised-controlled trial

Background: Scoliosis surgeries in adults often have a high risk of massive blood loss and significant transfusion of blood products during and after surgery. It is not known whether early cryoprecipitate therapy is useful in reducing blood loss and transfusion requirements. The objective of this ra...

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Bibliographic Details
Published in:Journal of perioperative practice 2024-03, Vol.34 (3), p.60-69
Main Authors: Ismail, Tarek I, Mahrous, Rabab SS
Format: Article
Language:English
Subjects:
Adult
Antifibrinolytic agents
Blood Loss, Surgical - prevention & control
Blood products
Blood Transfusion
Blood transfusions
Clinical trials
Hemorrhage
Humans
Neurosurgical Procedures
Prospective Studies
Scoliosis
Scoliosis - surgery
Surgery
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Summary:Background: Scoliosis surgeries in adults often have a high risk of massive blood loss and significant transfusion of blood products during and after surgery. It is not known whether early cryoprecipitate therapy is useful in reducing blood loss and transfusion requirements. The objective of this randomised, prospective placebo control study was to evaluate whether prophylactic administration of cryoprecipitate would reduce blood loss and transfusion requirements during scoliosis surgery. Methods: Eighty adult patients scheduled to undergo elective scoliosis correction were randomly assigned to receive either ten units of cryoprecipitate before incision (cryo group) or an equivalent volume of 0.9% saline (placebo group). Blood loss, transfusion requirements, coagulation parameters and complications were assessed. Results: No significant differences were found in the volume of transfused blood products, intraoperative estimated blood loss between the intervention and placebo groups. Postoperative blood loss was significantly lower in the cry group when compared to the other group. During adult surgical correction of scoliosis, prophylactic administration of cryoprecipitate did not diminish the amount of transfused blood products or decrease intraoperative blood loss. Conclusion: It could be concluded that the prophylactic administration of cryoprecipitate shows no differences in intraoperative blood loss and transfusion requirements during scoliosis surgery.
ISSN:1750-4589
2515-7949
DOI:10.1177/17504589221132393