Evaluation of deep gray matter for early brain development using quantitative susceptibility mapping

• Published in: European radiology 2023-06, Vol.33 (6), p.4488-4499
• Main Authors: Otani, Sayo, Fushimi, Yasutaka, Iwanaga, Kogoro, Tomotaki, Seiichi, Shimotsuma, Taiki, Nakajima, Satoshi, Sakata, Akihiko, Okuchi, Sachi, Hinoda, Takuya, Wicaksono, Krishna Pandu, Takita, Junko, Kawai, Masahiko, Nakamoto, Yuji
• Format: Article
• Language: English
• Subjects: Age; Basal ganglia; Brain - diagnostic imaging; Brain mapping; Brain Mapping - methods; Caudate Nucleus; Child; Correlation; Cross-Sectional Studies; Diagnostic Radiology; Evaluation; Ganglia; Globus pallidus; Gray Matter - diagnostic imaging; Group dynamics; Humans; Imaging; Internal Medicine; Interventional Radiology; Iron; Magnetic permeability; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Magnetic susceptibility; Mapping; Medicine; Medicine & Public Health; Neuro; Neuroradiology; Newborn babies; Patients; Pediatrics; Putamen; Radiology; Substantia grisea; Susceptibility; Thalamus; Ultrasound
• ISSN: 1432-1084; 0938-7994; 1432-1084
• DOI: 10.1007/s00330-022-09267-4

Objectives To evaluate susceptibility values associated with iron accumulation in the deep gray matter during postnatal development and to compare magnetic susceptibility between patients with normal and delayed development. Methods Patients with postmenstrual age (PMA) ≤ 1000 days underwent MR scans between August 2015 and April 2020 at our hospital. Quantitative susceptibility mapping (QSM) was performed, and magnetic susceptibility was measured using three-dimensional volumes of interest (VOIs) for the caudate nucleus (CN), globus pallidus (GP), putamen (PT), and ventrolateral thalamic nucleus (VL). Cross-sectional analysis was performed for 99 patients with normal development and 39 patients with delayed development. Longitudinal analysis was also performed to interpret changes over time in 13 patients with normal development. Correlations between magnetic susceptibility in VOIs and PMA or chronological age (CA) were assessed. Results Susceptibility values for CN, GP, PT, and VL showed positive moderate correlations with both PMA ( ρ = 0.45, 0.69, 0.62, and 0.33, respectively) and CA ( ρ = 0.53, 0.69, 0.66, and 0.39, respectively). The slope of the correlation between susceptibility values and age was highest in the GP among the four gray matter areas. Susceptibility values for the CN, GP, PT, and VL were higher with normal development than with delayed development at early postnatal age, although a significant difference was only observed for the CN. Susceptibility values also increased with age in the longitudinal analysis. Conclusions Magnetic susceptibility values in deep gray matter increased with age ≤ 1000 days. The normal development group showed higher susceptibility values than the delayed development group at early postnatal age (PMA ≤ 285 days). Key Points • Magnetic susceptibilities in deep gray matter nuclei increased with age (postmenstrual age ≤ 1000 days) in a large number of pediatric patients. • The normal development group showed higher susceptibility values than the delayed development group in the basal ganglia and ventrolateral thalamic nucleus at early postnatal age (PMA ≤ 285 days).