Association of sarcoidosis with psoriasis: a cross-sectional study in the All of Us research program

Psoriasis and sarcoidosis are inflammatory skin and systemic diseases that may share a similar immunopathogenesis involving a Th1 and/or Th17 polarized immune response. Although the coexistence of sarcoidosis and psoriasis in the same individuals has been reported, the potential association between...

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Bibliographic Details
Published in:Archives of dermatological research 2023-07, Vol.315 (5), p.1439-1441
Main Authors: Murphy, Michael J., Leasure, Audrey C., Damsky, William, Cohen, Jeffrey M.
Format: Article
Language:English
Subjects:
Coexistence
Cross-Sectional Studies
Dermatology
Helper cells
Humans
Immune response
Immunopathogenesis
Lymphocytes T
Medicine
Medicine & Public Health
Population Health
Psoriasis
Sarcoidosis
Short Report
Skin
Skin diseases
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Summary:Psoriasis and sarcoidosis are inflammatory skin and systemic diseases that may share a similar immunopathogenesis involving a Th1 and/or Th17 polarized immune response. Although the coexistence of sarcoidosis and psoriasis in the same individuals has been reported, the potential association between these diseases at a population-level in the United States has not been evaluated. To evaluate this association, we performed a matched cross-sectional study in the All of Us research program database. In the multivariable analysis of 4932 psoriasis cases and 19,728 controls, sarcoidosis was found to be significantly associated with psoriasis (OR 2.37 [95% CI 1.73–3.23], p 
ISSN:1432-069X
0340-3696
1432-069X
DOI:10.1007/s00403-022-02488-z