The role of NOD2 in intestinal immune response and microbiota modulation: A therapeutic target in inflammatory bowel disease

•NOD2 has advantages and disadvantages in different immune environments.•Various posttranslational modifications affect the function of NOD2 and its signaling pathways on immune cells.•Interaction and functional effects between various MIRNAs with NOD2 and related molecules.•NOD2 and similar molecul...

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Bibliographic Details
Published in:International immunopharmacology 2022-12, Vol.113, p.109466-109466, Article 109466
Main Authors: Liu, Ziyue, Zhang, Yaqin, Jin, Tao, Yi, Chengxue, Ocansey, Dickson Kofi Wiredu, Mao, Fei
Format: Article
Language:English
Subjects:
IBD
Immune response
Microbiota
miRNA
NOD2
Therapeutic target
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Summary:•NOD2 has advantages and disadvantages in different immune environments.•Various posttranslational modifications affect the function of NOD2 and its signaling pathways on immune cells.•Interaction and functional effects between various MIRNAs with NOD2 and related molecules.•NOD2 and similar molecules show promise as targets for the diagnosis and treatment of IBD. As an intracellular pattern recognition receptor (PPR), the nucleotide-binding oligomerization domain-containing protein 2 (NOD2) triggers a cascade of immune responses. Previous studies of NOD2 regarding inflammatory bowel disease (IBD) mainly focused on the relevance of NOD2 mutations and loss within the disease onset and progression. With increasing research, more studies are exploring other functional roles and clinical applications of NOD2. In this review, we discuss the role of NOD2 in intestinal immune response and microbiota modulation in IBD and explore its clinical potential as a therapeutic target for IBD.
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2022.109466