Nickel‐Catalyzed Reductive Coupling of Chlorosilanes

Organosilanes play essential roles in many important research areas. The use of readily available chlorosilanes to catalytically access these compounds is synthetically appealing but remains a long‐standing challenge. Nickel‐catalyzed reductive cross‐coupling reaction has recently emerged as a promi...

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Bibliographic Details
Published in:Chemistry : a European journal 2023-02, Vol.29 (11), p.e202203362-n/a
Main Authors: Pang, Xiaobo, Shu, Xing‐Zhong
Format: Article
Language:English
Subjects:
Chemistry
Chlorosilanes
Couplings
Cross coupling
Functional groups
Nickel
silicon
silylation
Structure-function relationships
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Summary:Organosilanes play essential roles in many important research areas. The use of readily available chlorosilanes to catalytically access these compounds is synthetically appealing but remains a long‐standing challenge. Nickel‐catalyzed reductive cross‐coupling reaction has recently emerged as a promising protocol to arrive at this goal. This strategy allows the chlorosilanes to be coupled with various carbon electrophiles under mild conditions. These reactions afford organosilanes with improved molecular diversity, structural complexity, and functional group compatibility. This Concept article summarizes the recent advance on nickel‐catalyzed reductive C−Si couplings of chlorosilanes. This Concept article summarizes the progress of the reductive coupling of chlorosilanes by nickel catalysis. This method enables cheap, stable, and readily available carbon and silicon reagents to be coupled, offering a mild and high functional‐group‐tolerance route to synthesize organosilanes.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202203362