HPV‐related cervical diseases: Alteration of vaginal microbiotas and promising potential for diagnosis

Vaginal microbiota is closely associated with women's health, however, the correlation between HPV‐related cervical disease (HRCD) and vaginal microbiota is still obscure. In this study, patients with HRCD (n = 98) and healthy controls (n = 58) in Hangzhou were recruited, and their vaginal micr...

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Published in:Journal of medical virology 2023-01, Vol.95 (1), p.e28351-n/a
Main Authors: Xu, Xiaoxian, Rao, Huiting, Fan, Xiaoji, Pang, Xiangwei, Wang, Yichen, Zhao, Lingqin, Xing, Jie, Lv, Xiaojuan, Wang, Tingzhang, Tao, Jin, Zhang, Xiaojing, Qian, Jianhua, Lou, Hanmei
Format: Article
Language:English
Subjects:
Algorithms
Biomarkers
Community composition
Composition
Diagnosis
Disease
disease prediction
Encyclopedias
Female
Genomes
HPV‐related cervical disease
Human papillomavirus
Human Papillomavirus Viruses
Humans
Microbiota
Microbiota - genetics
Microorganisms
Papillomaviridae - genetics
Papillomavirus Infections - complications
Papillomavirus Infections - diagnosis
random forest
RNA, Ribosomal, 16S - genetics
Statistical analysis
Vagina
vaginal microbiota
Virology
Womens health
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Summary:Vaginal microbiota is closely associated with women's health, however, the correlation between HPV‐related cervical disease (HRCD) and vaginal microbiota is still obscure. In this study, patients with HRCD (n = 98) and healthy controls (n = 58) in Hangzhou were recruited, and their vaginal microbiota were collected and analyzed. The composition of the vaginal microbial community was explored, and a disease classification model was developed by random forest algorithm. The results suggested that the diversity of vaginal microbiota was significantly higher in HRCDs than that in healthy controls (p 
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.28351