Transcapillary escape rate of albumin in humans during exercise-induced hypervolemia

Andrew Haskell, Ethan R. Nadel, Nina S. Stachenfeld, Kei Nagashima, and Gary W. Mack The John B. Pierce Laboratory and Departments of Epidemiology and Public Health and of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06519 Received 16 December 1996; a...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 1997-08, Vol.83 (2), p.407-413
Main Authors: Haskell, Andrew, Nadel, Ethan R, Stachenfeld, Nina S, Nagashima, Kei, Mack, Gary W
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Capillaries - metabolism
Capillary Permeability
Colloids - metabolism
Exercise
Extracellular Space - metabolism
Female
Fundamental and applied biological sciences. Psychology
Humans
Hydrostatic Pressure
Hyperemia - metabolism
Male
Microcirculation
Muscle, Skeletal - blood supply
Osmotic Pressure
Plasma Volume
Serum Albumin - metabolism
Skin - blood supply
Space life sciences
Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
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Summary:Andrew Haskell, Ethan R. Nadel, Nina S. Stachenfeld, Kei Nagashima, and Gary W. Mack The John B. Pierce Laboratory and Departments of Epidemiology and Public Health and of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06519 Received 16 December 1996; accepted in final form 2 April 1997. Haskell, Andrew, Ethan R. Nadel, Nina S. Stachenfeld, Kei Nagashima, and Gary W. Mack. Transcapillary escape rate of albumin in humans during exercise-induced hypervolemia. J. Appl. Physiol. 83(2): 407-413, 1997. To test the hypotheses that plasma volume (PV) expansion 24 h after intense exercise is associated with reduced transcapillary escape rate of albumin (TER alb ) and that local changes in transcapillary forces in the previously active tissues favor retention of protein in the vascular space, we measured PV, TER alb , plasma colloid osmotic pressure (COP p ), interstitial fluid hydrostatic pressure (Pi), and colloid osmotic pressure in leg muscle and skin and capillary filtration coefficient (CFC) in the arm and leg in seven men and women before and 24 h after intense upright cycle ergometer exercise. Exercise expanded PV by 6.4% at 24 h (43.9 ± 0.8 to 46.8 ± 1.2 ml/kg, P  
ISSN:8750-7587
1522-1601
DOI:10.1152/jappl.1997.83.2.407