Assessment of cognitive function and its predictors in patients with multiple sclerosis: a case–control study

Introduction Cognitive dysfunction can be seen in patients with MS (PwMS) and has been gaining attention in recent years. This study aimed to assess cognitive function and its determinants in PwMS using Addenbrooke Cognitive Assessment Battery (ACE-R). Material and methods This case–control study wa...

Full description

Saved in:
Bibliographic Details
Published in:Neurological sciences 2023-03, Vol.44 (3), p.1009-1016
Main Authors: Basci, Dila, Tulek, Zeliha
Format: Article
Language:English
Subjects:
Anxiety
Case-Control Studies
Child
Cognition
Cognitive ability
Cognitive Dysfunction - complications
Cognitive Dysfunction - etiology
Fatigue - complications
Fatigue - etiology
Humans
Medicine
Medicine & Public Health
Memory
Mental depression
Multiple sclerosis
Multiple Sclerosis - complications
Multiple Sclerosis - diagnosis
Multiple Sclerosis - psychology
Neurology
Neuropsychological Tests
Neuroradiology
Neurosciences
Neurosurgery
Original Article
Psychiatry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction Cognitive dysfunction can be seen in patients with MS (PwMS) and has been gaining attention in recent years. This study aimed to assess cognitive function and its determinants in PwMS using Addenbrooke Cognitive Assessment Battery (ACE-R). Material and methods This case–control study was conducted at an outpatient MS clinic in Istanbul. The sample consisted of 60 consecutive patients with definite MS and 60 matched controls. Cognitive function was evaluated by using the ACE-R. Subjective cognitive function, anxiety, depression, and fatigue were evaluated by validated scales. Results The mean age of the patients was 38.8, and the time since diagnosis was nine years. The majority of the patients had relapsing–remitting MS. Compared to age, sex, and education-matched healthy controls, all ACE-R scores, attention/orientation ( p  = 0.020), memory ( p  = 0.003), verbal fluency ( p  = 0.002), language ( p  = 0.002), visuospatial ( p  = 0.001), and general cognitive functioning ( p  
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-022-06524-8