Teeth with acute apical abscess vs. teeth with chronic apical periodontitis: a quantitative and qualitative proteomic analysis

Objective To quantitatively and qualitatively analyze the proteomic profile of teeth with acute apical abscesses (AAA) compared with teeth with chronic apical periodontitis (CAP) and to correlate the expression of detected human proteins with their main biological functions. Materials and methods Sa...

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Bibliographic Details
Published in:Clinical oral investigations 2023-02, Vol.27 (2), p.591-601
Main Authors: Loureiro, Caroline, Buzalaf, Marília Afonso Rabelo, Ventura, Talita Mendes Oliveira, Pelá, Vinícius Taioqui, Rodrigues, Gladiston William Lobo, Andrade, Júlia Guerra, Pessan, Juliano Pelim, Jacinto, Rogério Castilho
Format: Article
Language:English
Subjects:
Abscess
Abscesses
Acute phase proteins
Cathepsin G
Cytoplasm
Dentistry
DNA repair
Extracellular matrix
Fibrinogen
Gelsolin
Gum disease
Hemopexin
Humans
Immune response
Liquid chromatography
Mass spectroscopy
Medicine
Moesin
Original Article
Oxidative stress
Periapical Periodontitis - therapy
Periodontitis
Proteins
Proteomics
Root canals
Stress response
Teeth
Transketolase
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Summary:Objective To quantitatively and qualitatively analyze the proteomic profile of teeth with acute apical abscesses (AAA) compared with teeth with chronic apical periodontitis (CAP) and to correlate the expression of detected human proteins with their main biological functions. Materials and methods Samples were obtained from root canals of 9 patients diagnosed with AAA and 9 with CAP. Samples were analyzed by reversed-phase liquid chromatography coupled to mass spectrometry. Label-free quantitative proteomic analysis was performed by Protein Lynx Global Service software. Differences in protein expression were calculated using the t -test ( p  
ISSN:1436-3771
1432-6981
1436-3771
DOI:10.1007/s00784-022-04754-w