Circular RNAs and tuberculosis infection

Tuberculosis (TB) is a deadly infectious disease caused by Mycobacterium tuberculosis (Mtb) that affects the immune system chronically. Therefore, effective control and treatment of tuberculosis requires rapid and accurate diagnostic strategies. Tuberculosis has always been a global burden on health...

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Published in:International journal of biological macromolecules 2023-01, Vol.226, p.1218-1225
Main Authors: Hemati, Zahra, Neamati, Foroogh, Khaledi, Mansoor, Gheibihayat, Seyed Mohammad, Jafarzadeh, Leila, Momen-Heravi, Mansooreh, Haddadi, Mohammad Hossein, Sameni, Fatemeh, Fathizadeh, Hadis
Format: Article
Language:English
Subjects:
Biomarker
Biomarkers - metabolism
CircRNAs
Circular RNAs
Humans
Mycobacterium tuberculosis
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - metabolism
Non-coding RNA
RNA - genetics
RNA - metabolism
RNA, Circular - genetics
Tuberculosis - diagnosis
Tuberculosis - genetics
Tuberculosis infection
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Summary:Tuberculosis (TB) is a deadly infectious disease caused by Mycobacterium tuberculosis (Mtb) that affects the immune system chronically. Therefore, effective control and treatment of tuberculosis requires rapid and accurate diagnostic strategies. Tuberculosis has always been a global burden on health, social and economic systems due to the lack of standard curative and diagnostic (bio)markers. Accordingly, the management and monitoring of patients with active TB at the primary care level may be possible through new, rapid and cost-effective non-sputum-based diagnostic procedures. Biomarkers can help diagnose various diseases, including circular RNA (circRNA), which has recently been introduced as an endogenous, abundant and stable RNA in the cytoplasm with unique tissue specificity. There are frequent reports of circRNA involvement in many pathological and physiological processes in human beings. Recent studies have highlighted the presence of circRNAs in serum and their role as promising biomarkers in the diagnosis of the disease, potentially due to the continuous, stable, closed covalent circular structures and lack of easy degradation by nucleases. The purpose of this review article is to scrutinize the behavior of circulating plasma RNAs in relation to the pathogenesis and diagnosis of tuberculosis.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2022.11.235