Calcofluor white-cholesteryl hydrogen succinate conjugate mediated liposomes for enhanced targeted delivery of voriconazole into Candida albicans

Fungal infections gradually lead to a high mortality rate due to difficulties in diagnosis, the limited number of antifungal drugs available, and the appearance of resistant isolates. Here, we developed a calcofluor white-cholesteryl hydrogen succinate conjugate (CFW-CHSc) as a novel nanomaterial th...

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Bibliographic Details
Published in:Biomaterials science 2022-12, Vol.11 (1), p.307-321
Main Authors: Liu, Wei, Li, Mengshun, Tian, Baocheng, Yang, Xuesong, Du, Wei, Wang, Xiuwen, Zhou, Huihui, Ding, Chen, Sai, Sixiang
Format: Article
Language:English
Subjects:
Animals
Antifungal Agents - pharmacology
Blood circulation
Candida albicans
Chains
Chitin
Conjugates
Cytoplasm
Dyes
Effectiveness
Fluorescence
Fungi
Fungicides
Hydrogen
Liposomes
Mice
Microbial Sensitivity Tests
Nanomaterials
Nanoparticles
Succinates
Voriconazole - pharmacology
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Summary:Fungal infections gradually lead to a high mortality rate due to difficulties in diagnosis, the limited number of antifungal drugs available, and the appearance of resistant isolates. Here, we developed a calcofluor white-cholesteryl hydrogen succinate conjugate (CFW-CHSc) as a novel nanomaterial that specifically binds to chitin chains in the cell wall. We showed that fluorescent-dye loaded CFW-CHSc-liposomes entered the cytoplasm of cells with increased efficacy. Voriconazole-loaded CFW-CHSc-liposomes displayed an increased antifungal activity against yeast cells in an assay. Animal infection models and animal imaging analysis showed that fluorescent-dye loaded CFW-CHSc-liposomes maintained prolonged residence in rodent tissues. In mouse liver and kidney tissue, voriconazole-loaded CFW-CHSc-liposomes showed significantly enhanced antifungal activity when administered intravenously. Taken together, our studies confirm that CFW-CHSc increases the drug delivery efficacy of nanoparticles by interacting with chitin chains in the cell wall. The fungi-targeting nanoparticles improve the drug delivery efficacy by enriching the nanoparticles at the site of fungal infection the blood circulation system. Fungi-targeting nanomaterials have a promising future in the treatment of nosomycosis.
ISSN:2047-4830
2047-4849
DOI:10.1039/d2bm01263d