Hemodynamic impacts of apelin-13 in a neonatal lamb model of septic peritonitis

Background Apelins are potential candidate therapeutic molecules for hemodynamic support. The objective of this study was to assess the hemodynamic impacts of apelin-13 in a neonatal lamb model of septic shock. Methods Lambs were randomized to receive apelin-13 or normal saline. Septic shock was ind...

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Published in:Pediatric research 2023-07, Vol.94 (1), p.129-134
Main Authors: Simard, Émile, Morin, Christophe, Coquerel, David, Chagnon, Frédéric, Nadeau, Charlène, Samson, Nathalie, Praud, Jean-Paul, Lesur, Olivier, Fortin-Pellerin, Étienne
Format: Article
Language:English
Subjects:
Animals
Basic Science Article
Hemodynamics
Medicine
Medicine & Public Health
Pediatric Surgery
Pediatrics
Peritonitis
Saline Solution - therapeutic use
Sepsis
Sheep
Shock, Septic - drug therapy
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Summary:Background Apelins are potential candidate therapeutic molecules for hemodynamic support. The objective of this study was to assess the hemodynamic impacts of apelin-13 in a neonatal lamb model of septic shock. Methods Lambs were randomized to receive apelin-13 or normal saline. Septic shock was induced by injecting a fecal slurry into the peritoneal cavity. Lambs underwent volume repletion (30 mL/kg over 1 h) followed by intravenous administration of 5 incremental doses (D) of apelin-13 (D1 = 0.039 to D5 = 19.5 µg/kg/h) or normal saline. Results Following fecal injection, mean arterial pressure (MAP) and cardiac index (CI) dropped in both groups ( p  
ISSN:0031-3998
1530-0447
DOI:10.1038/s41390-022-02407-y