Iron‐Catalysed [3+3] Annulation of Oxime Acetates and Enaminones towards the Synthesis of Multi‐Substituted Pyridines

A direct access to unsymmetrical and symmetrical multi‐substituted pyridines has been accomplished via iron‐catalysed [3+3] annulation of oxime acetates with enaminones. This protocol is featured by easily available starting materials, no requirement of expensive additives and ligands, operational s...

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Bibliographic Details
Published in:Chemistry, an Asian journal an Asian journal, 2023-01, Vol.18 (1), p.e202201004-n/a
Main Authors: Bodala, Varaprasad, Podugu, Rajitha Lakshmi, Yettula, Kumari, Gollamudi, Padmarao, Vidavalur, Siddaiah, Pulipaka, Shyamala
Format: Article
Language:English
Subjects:
Acetates
Additives
Catalysis
Chemical reactions
Chemistry
Enaminones
FeCl3
Functional groups
Iron
Organic chemistry
Oxime acetates
Oximes
Pyridines
Substituted pyridines
Substitutes
Terpyridine
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Summary:A direct access to unsymmetrical and symmetrical multi‐substituted pyridines has been accomplished via iron‐catalysed [3+3] annulation of oxime acetates with enaminones. This protocol is featured by easily available starting materials, no requirement of expensive additives and ligands, operational simplicity, and good tolerance with diverse functional groups. An efficient approach for the synthesis of unsymmetrical and symmetrical multi‐substituted pyridines is demonstrated. This process is preceded via iron−catalysed [3+3] annulation of oxime acetates with enaminones. Operational simplicity, use of easily available starting materials and inexpensive catalyst, avoiding the use of additives or ligands are the major advantages of this protocol.
ISSN:1861-4728
1861-471X
DOI:10.1002/asia.202201004