Use of bempedoic acid for LDL cholesterol lowering and cardiovascular risk reduction: a consensus document from the Italian study group on atherosclerosis, thrombosis and vascular biology

The clinical benefit of LDL cholesterol (LDL-C) lowering for cardiovascular disease prevention is well documented. This paper from the Italian Study Group on Atherosclerosis, Thrombosis and Vascular Biology summarizes current recommendations for treatment of hypercholesterolemia, barriers to lipid-l...

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Published in:Vascular pharmacology 2023-02, Vol.148, p.107137-107137, Article 107137
Main Authors: Patti, Giuseppe, Cavallari, Ilaria, Cesaro, Arturo, Gragnano, Felice, Riva, Letizia, Fimiani, Fabio, Cuccia, Claudio, Fresco, Claudio, Calabrò, Paolo, Leonardi, Sergio, Marcucci, Rossella, Rubboli, Andrea
Format: Article
Language:English
Subjects:
Atherosclerosis - diagnosis
Atherosclerosis - drug therapy
Atherosclerosis - prevention & control
Bempedoic acid
Biology
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - prevention & control
Cholesterol, LDL
Consensus
Dyslipidaemia
Fatty Acids
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
LDL cholesterol
Risk Factors
Thrombosis - drug therapy
Thrombosis - prevention & control
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Summary:The clinical benefit of LDL cholesterol (LDL-C) lowering for cardiovascular disease prevention is well documented. This paper from the Italian Study Group on Atherosclerosis, Thrombosis and Vascular Biology summarizes current recommendations for treatment of hypercholesterolemia, barriers to lipid-lowering therapy implementation and tips to overcome them, as well as available evidence on the efficacy and safety of bempedoic acid. We also report an updated therapeutic algorithm for pharmacological LDL-C lowering in view of the introduction of bempedoic acid in clinical practice. [Display omitted]
ISSN:1537-1891
1879-3649
DOI:10.1016/j.vph.2022.107137