Evaluation of hydroxamate-based resins towards a more clinically viable 44Ti/44Sc radionuclide generator

Several hydroxamate-based resins were synthesized and tested for use in 44Ti/44Sc generator systems in small scale experiments (740 kBq 44Ti). The most promising resin was tested further in larger scale generator studies (37 MBq). This resin displayed impressive retention of 44Ti over several elutio...

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Bibliographic Details
Published in:Applied radiation and isotopes 2023-02, Vol.192, p.110588-110588, Article 110588
Main Authors: Gajecki, Leah, Marino, Celine M., Cutler, Cathy S., Sanders, Vanessa A.
Format: Article
Language:English
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Summary:Several hydroxamate-based resins were synthesized and tested for use in 44Ti/44Sc generator systems in small scale experiments (740 kBq 44Ti). The most promising resin was tested further in larger scale generator studies (37 MBq). This resin displayed impressive retention of 44Ti over several elutions, and high quantities of 44Sc were obtained in small volumes of dilute HCl eluents. Initial radiolabeling experiments were conducted and demonstrated the possibility of direct radiolabeling of the generator produced 44Sc with DOTA. •Novel hydroxamate resin for use in 44Ti/44Sc radionuclide generator.•Clinically viable generator system.•Direct radiolabeling.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2022.110588