Bioactive Arylnaphthalide Lignans from Justicia depauperata

Eleven previously undescribed arylnaphthalide lignans (1–11) together with seven known compounds were isolated from the whole plant of Justicia depauperata. The structures of 1–11 were elucidated by spectroscopic analysis and mass spectrometry. Compounds 6 (IC50 = 4.1 μM) and 9 (IC50 = 9.5 μM) displ...

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Published in:Journal of natural products (Washington, D.C.) D.C.), 2022-12, Vol.85 (12), p.2731-2739
Main Authors: Tchegnitegni Toussie, Billy, Nguengang, Ruland Tchuinkeu, Mawabo, Isabelle Kamga, Teponno, Rémy Bertrand, Kezetas Bankeu, Jean Jules, Chouna, Jean Rodolphe, Nkenfou, Celine Ngeufeu, Tapondjou, Léon Azefack, Sewald, Norbert, Lenta, Bruno Ndjakou
Format: Article
Language:English
Subjects:
Acanthaceae - chemistry
Drugs, Chinese Herbal - chemistry
Justicia - chemistry
Lignans - chemistry
Lignans - pharmacology
Molecular Structure
Plant Extracts - chemistry
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Summary:Eleven previously undescribed arylnaphthalide lignans (1–11) together with seven known compounds were isolated from the whole plant of Justicia depauperata. The structures of 1–11 were elucidated by spectroscopic analysis and mass spectrometry. Compounds 6 (IC50 = 4.1 μM) and 9 (IC50 = 9.5 μM) displayed cytotoxic activity against the KB-3-1 cervical carcinoma cell line. This report provides an insight into the conformational equilibria occurring in the arylnaphthalide lignan constituents of this plant.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.2c00624