Identification of SNPs and expression patterns of ALB, AHSG and GC genes and their association with growth traits in Hu sheep

• Published in: Gene 2023-02, Vol.853, p.147100-147100, Article 147100
• Main Authors: Zhao, Liming, Wang, Weimin, Wang, Xiaojuan, Zhang, Deyin, Li, Xiaolong, Zhao, Yuan, Zhang, Yukun, Xu, Dan, Cheng, Jiangbo, Wang, Jianghui, Li, Wenxin, Lin, Changchun, Wu, Weiwei, Zhang, Xiaoxue, Zheng, Wenxin
• Format: Article
• Language: English
• Subjects: AHSG; ALB; Animals; Association; Body Weight - genetics; Genes, Regulator; Genotype; Growth traits; Hu sheep; Male; Phenotype; Polymorphism, Single Nucleotide; qRT-PCR; Sheep - genetics; SNP
• ISSN: 0378-1119; 1879-0038
• DOI: 10.1016/j.gene.2022.147100

•The SNP of ALB was significantly associated with ADG.•The SNP of AHSG was significantly associated with ADG and FCR.•The SNP of GC was significantly associated with BW, BH and BL.•ALB, AHSG, and GC expression levels were significantly higher in H_BW group. Growth traits are economically important traits in sheep breeding. This study was conducted to evaluate the polymorphisms of ALB, AHSG and GC genes and their association with growth traits in Hu sheep. We measured and recorded the body weight (BW), body height (BH), body length (BL) and feed conversion ratio (FCR) of 1418 male Hu sheep raised in the same environment from 80 to 180 days of age. The total of four SNPs in the ALB, AHSG and GC genes were identified by direct sequencing technology. The results of association analysis showed that two loci (g.8699 A>T and g.13458 T>C) of ALB gene significantly affect average daily gain (ADG; P C in AHSG gene were significantly associated with ADG and FCR (P C and BW, BH and BL (P C, AHSG g.2454 T>C and GC g.19484 A>C loci are potential molecular markers for Hu sheep breeding.