Haplotype structure of MSTN, IGF1, and BMP2 genes in Tunisian goats (Capra hircus) and their association with morphometric traits

The aim of the present study was to evaluate variability and haplotype structure of twenty-eight single nucleotide polymorphisms (SNPs) at myostatin ( MSTN ), insulin-like growth factor 1 ( IGF1 ), and bone morphogenetic protein 2 ( BMP2 ) genes. Association between the polymorphic SNPs and morphome...

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Bibliographic Details
Published in:Tropical animal health and production 2023-02, Vol.55 (1), p.2-2, Article 2
Main Authors: Chalbi, Sarra, Dettori, Maria Luisa, Djemali, M’Naouer, Vacca, Giuseppe Massimo, Petretto, Elena, Pazzola, Michele, Bedhiaf-Romdhani, Sonia
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Body length
Bone morphogenetic protein 2
bone morphogenetic proteins
Capra hircus
Chest
ears
Genes
Genomes
Goats
Goats - genetics
Growth factors
Haplotypes
head
Igf1 gene
Insulin
Insulin-like growth factor I
Insulin-Like Growth Factor I - genetics
Insulin-like growth factors
Life Sciences
Linkage disequilibrium
morphometry
Musculoskeletal system
Myostatin
Nucleotides
Proteins
Regular Articles
Single-nucleotide polymorphism
tail
Veterinary Medicine/Veterinary Science
Zoology
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Summary:The aim of the present study was to evaluate variability and haplotype structure of twenty-eight single nucleotide polymorphisms (SNPs) at myostatin ( MSTN ), insulin-like growth factor 1 ( IGF1 ), and bone morphogenetic protein 2 ( BMP2 ) genes. Association between the polymorphic SNPs and morphometric traits was performed on a population of 263 Tunisian goats. The SNPs analyzed were all polymorphic (except one), and the three genes had different haplotype structures. Significant association of SNPs at MSTN with head length was highlighted in the Tunisian goats. The variability at IGF1 gene was associated with body length, ear length, tail length, and chest depth. For BMP2 , significant association was revealed with chest depth. Significant association was also detected between linkage disequilibrium (LD) block 2 at IGF1 with body length. These findings might play a potential role in gene-assisted programs.
ISSN:0049-4747
1573-7438
DOI:10.1007/s11250-022-03403-4