Inflammation and Performance Status: The Cornerstones of Prognosis in Advanced Cancer

In advanced cancer, although performance status (PS), systemic inflammatory response and nutritional status are known to have prognostic value, geographical variations and sociodemographic indexes may also impact survival. This study compares validated prognostic factors in two international cohorts...

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Bibliographic Details
Published in:Journal of pain and symptom management 2023-04, Vol.65 (4), p.348-357
Main Authors: Rocha, Bruna M.M., Dolan, Ross D., Paiva, Carlos E., McGovern, Josh, Paiva, Bianca S.R., Preto, Daniel D., McMillan, Donald C., Maia, Yara C.P., Laird, Barry J.
Format: Article
Language:English
Subjects:
Advanced cancer
Humans
Inflammation
Neoplasms - diagnosis
Neoplasms - therapy
performance status
Prognosis
Proportional Hazards Models
Prospective Studies
Retrospective Studies
survival analysis
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Summary:In advanced cancer, although performance status (PS), systemic inflammatory response and nutritional status are known to have prognostic value, geographical variations and sociodemographic indexes may also impact survival. This study compares validated prognostic factors in two international cohorts and establishes a prognostic framework for treatment. Two international biobanks of patients (n=1.518) with advanced cancer were analyzed. Prognostic factors (Eastern Cooperative Oncology Group Performance Status [ECOG-PS], body mass index [BMI] and modified Glasgow Prognostic Score [mGPS]) were assessed. The relationship between these and survival was examined using Kaplan–Meier and Cox regression methods. According to multivariate analysis, in the European cohort the most highly predictive factors were BMI 28 kg/m2) to 44% (mGPS 2, BMI
ISSN:0885-3924
1873-6513
DOI:10.1016/j.jpainsymman.2022.11.021