A Genetic Assessment of Dopamine Agonist-Induced Impulse Control Disorder in Patients With Prolactinoma

Abstract Context Dopamine agonist (DA)–induced impulse control disorder (ICD) represents a group of behavioral disorders that are increasingly recognized in patients with prolactinoma. Objective We aimed to examine the genetic component of the underlying mechanism of DA-induced ICD. Methods Patients...

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Published in:The journal of clinical endocrinology and metabolism 2023-06, Vol.108 (6), p.e275-e282
Main Authors: Sahin, Serdar, Sudutan, Tugce, Kavla, Yasin, Durcan, Emre, Özogul, Yeliz Yagiz, Poyraz, Burc Cagri, Sayitoglu, Muge, Ozkaya, Hande Mefkure, Kadioglu, Pinar
Format: Article
Language:English
Subjects:
Adenoma
Agonists
Cabergoline
Care and treatment
Disruptive, Impulse Control, and Conduct Disorders - chemically induced
Disruptive, Impulse Control, and Conduct Disorders - genetics
Dopamine
Dopamine Agonists - adverse effects
Dopamine D1 receptors
Dopamine D3 receptors
Dopamine receptors
Ethylenediaminetetraacetic acid
Genes
Genetic aspects
Health aspects
Humans
Impulsive behavior
Medical research
Medicine, Experimental
Mental illness
Neurophysiology
Neurotransmission
Phenols
Pituitary
Pituitary gland
Pituitary Neoplasms - drug therapy
Pituitary Neoplasms - genetics
Prolactin
Prolactinoma - drug therapy
Prolactinoma - genetics
Serotonin Plasma Membrane Transport Proteins
Tumors
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Summary:Abstract Context Dopamine agonist (DA)–induced impulse control disorder (ICD) represents a group of behavioral disorders that are increasingly recognized in patients with prolactinoma. Objective We aimed to examine the genetic component of the underlying mechanism of DA-induced ICD. Methods Patients with prolactinoma receiving dopamine agonist (cabergoline) treatment were included in the study. These patients were divided into 2 groups: patients who developed ICD due to DA and patients who did not. Patients were evaluated for polymorphisms of the DRD1, DRD3, COMT, DDC, GRIN2B, TPH2, OPRK1, OPRM1, SLC6A4, SLC6A3, HTR2A genes. Results Of the 72 patients with prolactinoma using cabergoline, 20 were diagnosed with ICD. When patients with and without ICD were compared according to genotype frequencies, OPRK1/rs702764, DRD3/rs6280, HTR2A/rs6313, SLC6A4/rs7224199, GRIN2B/rs7301328, TPH2/rs7305115, COMT/rs4680, DRD1/rs4532 polymorphisms significantly increased in patients with DA-induced ICD. Conclusion Our results show that multiple neurotransmission systems affect DA-induced ICD in patients with prolactinoma.
ISSN:0021-972X
1945-7197
DOI:10.1210/clinem/dgac718