Ovarian removal and subsequent breast cancer prognosis: a nationwide cohort study

Purpose To evaluate whether previous ovarian removal concomitant with benign hysterectomy improves prognosis in a cohort of women with breast cancer. Methods In this nationwide register-based cohort study, risk of recurrence and mortality were examined in 4563 women with invasive breast cancer and p...

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Bibliographic Details
Published in:Breast cancer research and treatment 2023-02, Vol.197 (3), p.583-591
Main Authors: Gottschau, Mathilde, Kjær, Susanne K., Viuff, Jakob Hansen, Jensen, Allan, Munk, Christian, Settnes, Annette, Mellemkjær, Lene
Format: Article
Language:English
Subjects:
Benign
Breast cancer
Breast Neoplasms - diagnosis
Breast Neoplasms - epidemiology
Breast Neoplasms - therapy
Cancer research
Cohort analysis
Cohort Studies
Epidemiology
Estrogen receptors
Female
Humans
Hysterectomy
Medical prognosis
Medicine
Medicine & Public Health
Menopause
Middle Aged
Mortality
Neoplasm Recurrence, Local - epidemiology
Oncology
Ovariectomy
Ovariectomy - methods
Ovaries
Post-menopause
Prognosis
Regression analysis
Tumors
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Summary:Purpose To evaluate whether previous ovarian removal concomitant with benign hysterectomy improves prognosis in a cohort of women with breast cancer. Methods In this nationwide register-based cohort study, risk of recurrence and mortality were examined in 4563 women with invasive breast cancer and previous bilateral salpingo-oophorectomy (BSO) concomitant with benign hysterectomy, during 1977–2018. Comparing with benign hysterectomy alone, hazard ratios (HRs) and 95% confidence intervals (CIs) were evaluated by Cox-proportional hazards regression models. Analyses were stratified on age at hysterectomy as a proxy for menopausal status (
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-022-06825-8