A new 1,2-diketone physalin isolated from Physalis minima and TRAIL-resistance overcoming activity of physalins

A new 1,2-diketone physalin, physalin XII ( 1 ), and 13 known compounds were isolated from the methanol extract of Physalis minima whole plant collected in Thailand. Among them, five physalins ( 2 – 6 ) had tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance overcoming activit...

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Bibliographic Details
Published in:Journal of natural medicines 2023-03, Vol.77 (2), p.370-378
Main Authors: Manome, Teruhisa, Hara, Yasumasa, Ishibashi, Masami
Format: Article
Language:English
Subjects:
Adenocarcinoma
Apoptosis
Bcl-2 protein
Biomedical and Life Sciences
Biomedicine
c-FLIP protein
Cell Line
Cell Line, Tumor
Complementary & Alternative Medicine
FLIP protein
Humans
Ligands
Medicinal Chemistry
Pharmacology/Toxicology
Pharmacy
Physalis
Physalis minima
Plant extracts
Plant Sciences
TRAIL protein
Tumor Necrosis Factor-alpha
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Summary:A new 1,2-diketone physalin, physalin XII ( 1 ), and 13 known compounds were isolated from the methanol extract of Physalis minima whole plant collected in Thailand. Among them, five physalins ( 2 – 6 ) had tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance overcoming activity, and physalin F ( 3 ) was the most active with an IC 50 value of 0.39 µM against human gastric adenocarcinoma cell line AGS in the presence of TRAIL (100 ng/mL). An investigation of the TRAIL-resistance overcoming activity of physalins using western blot analysis showed that 3 promoted TRAIL-induced apoptosis by suppressing anti-apoptotic proteins c-FLIP and Bcl-2.
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-022-01670-x