IgG antibody response by ELISA using Wuhan and Lambda variant antigens in BBIBP-CORV vaccinated health care workers

. To evaluate the IgG antibody response by ELISA using Wuhan and Lambda antigens in health care workers with and without history of SARS-CoV-2 infection prior to immunization with the first and second doses of Sinopharm vaccine (BBIBP-CorV). . An analytical study was carried out in health care worke...

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Bibliographic Details
Published in:Revista peruana de medicina experimental y salud pública 2022-07, Vol.39 (3), p.267
Main Authors: García-Mendoza, María, Merino-Sarmiento, Nancy, De Lucio-Burga, Gabriel, Fernández-Navarro, Manuel G, Pampa-Espinoza, Luis, Solis-Sánchez, Gilmer, Huaringa-Núñez, Maribel, Palomino-Rodríguez, Miryam, Ríos-Monteza, Pamela, Solari, Lely
Format: Article
Language:eng ; spa
Subjects:
Adolescent
Adult
Antibody Formation
COVID-19
Health Personnel
Humans
Immunoglobulin G
SARS-CoV-2
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Summary:. To evaluate the IgG antibody response by ELISA using Wuhan and Lambda antigens in health care workers with and without history of SARS-CoV-2 infection prior to immunization with the first and second doses of Sinopharm vaccine (BBIBP-CorV). . An analytical study was carried out in health care workers over 18 years of age. Fifty-one participants with history and 100 participants without history of SARS-CoV-2 infection, who received two doses of Sinopharm vaccine, were included. IgG antibodies were assessed 21 days after the first dose, 21 days after the second dose and 3 months after the second dose by in-house ELISA using the complete antigen of the Wuhan variant (B.1.1) and lambda variant (C-37) of SARS-CoV-2 virus. . Both groups showed a large increase in the percentage of people with antibodies after the second dose, however, this percentage decreased 3 months after the second dose. The difference between the antibody index measured by ELISA with Wuhan variant antigen versus the ELISA with lambda variant was significant (p
ISSN:1726-4642
1726-4642
DOI:10.17843/rpmesp.2022.393.10875