Burden of neutropenia and leukopenia among adult kidney transplant recipients: A systematic literature review of observational studies

Background Leukopenia and neutropenia (L/N) may affect treatment decisions, potentially resulting in poor clinical and economic outcomes among kidney transplant recipients (KTRs). The burden of L/N is poorly quantified systematically. This systematic literature review aimed to summarize the incidenc...

Full description

Saved in:
Bibliographic Details
Published in:Transplant infectious disease 2023-02, Vol.25 (1), p.e14000-n/a
Main Authors: Raval, Amit D., Kistler, Kristin D., Tang, Yuexin, Vincenti, Flavio
Format: Article
Language:English
Subjects:
Adult
Anemia - etiology
Cotrimoxazole
Cytomegalovirus
Economics
Epidemiology
Graft rejection
Graft Rejection - epidemiology
Grafts
Granulocyte Colony-Stimulating Factor - therapeutic use
Humans
Immunosuppressive agents
Immunosuppressive Agents - therapeutic use
Kidney transplantation
Kidney Transplantation - adverse effects
Kidney transplants
Kidneys
Leukocytes
Leukocytes (granulocytic)
Leukocytes (neutrophilic)
Leukopenia
Leukopenia - etiology
Literature reviews
Mycophenolic acid
Mycophenolic Acid - therapeutic use
Neutropenia
Neutropenia - chemically induced
Observational studies
Opportunistic Infections - drug therapy
Rejection
Risk factors
Risk management
Systematic review
Tacrolimus
Thymoglobulin
Transplant Recipients
Valganciclovir - therapeutic use
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Leukopenia and neutropenia (L/N) may affect treatment decisions, potentially resulting in poor clinical and economic outcomes among kidney transplant recipients (KTRs). The burden of L/N is poorly quantified systematically. This systematic literature review aimed to summarize the incidence of, risk factors for, and clinical and economic outcomes associated with L/N post‐KT. Methods We systematically searched MEDLINE, Embase, and the Cochrane Library (from database inception‐June 14, 2021) and conferences (past 3 years) to identify observational studies examining epidemiology, risk factors, or outcomes associated with L/N among adult KTRs. Results Of 2081 records, 82 studies met inclusion criteria. Seventy‐three studies reported the epidemiology of L/N post‐KT. Pooled incidence of neutropenia, defined as absolute neutrophil counts (ANC)
ISSN:1398-2273
1399-3062
DOI:10.1111/tid.14000