Impact of high MELD scores on CMV viremia following liver transplantation

Introduction Advanced liver disease or cirrhosis is associated with an increased risk of infections; however, the impact of high pretransplant model for end‐stage liver disease (MELD) score on cytomegalovirus (CMV) viremia after liver transplantation is unknown. Methods This single‐center, retrospec...

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Bibliographic Details
Published in:Transplant infectious disease 2023-02, Vol.25 (1), p.e14001-n/a
Main Authors: Freedman, Sari R., Saunders, Kenneth, Plazak, Michael E., Ravichandran, Bharath R., Saharia, Kapil K., Masters, Brian M., Sparkes, Tracy
Format: Article
Language:English
Subjects:
Antiviral Agents - therapeutic use
Biopsy
Cirrhosis
CMV
Cohort Studies
Cytomegalovirus
Cytomegalovirus Infections - prevention & control
Disease resistance
End Stage Liver Disease - complications
Ganciclovir - therapeutic use
Graft rejection
Hazard assessment
Health risks
Humans
IgG antibody
Immunoglobulin G
Leukopenia
Liver
Liver diseases
liver transplant
Liver transplantation
Liver Transplantation - adverse effects
Liver transplants
MELD
Prophylaxis
Retrospective Studies
Risk
Severity of Illness Index
Thrombocytopenia
Thrombocytopenia - complications
Thrombocytopenia - drug therapy
Transplantation
Viremia
Viremia - drug therapy
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Summary:Introduction Advanced liver disease or cirrhosis is associated with an increased risk of infections; however, the impact of high pretransplant model for end‐stage liver disease (MELD) score on cytomegalovirus (CMV) viremia after liver transplantation is unknown. Methods This single‐center, retrospective, cohort study evaluated CMV high‐risk (CMV immunoglobulin G D+/R−) liver transplant recipients who received valganciclovir prophylaxis for 3 months between 2009 and 2019. Patients were stratified by pretransplant MELD score of
ISSN:1398-2273
1399-3062
DOI:10.1111/tid.14001