TNFSF13B rs9514828 gene polymorphism and soluble B cell activating factor levels: Association with apical periodontitis

Aim The aim of this case‐control study was to evaluate the association between the TNFSF13B rs9514828 (−871 C > T) polymorphism and soluble BAFF (sBAFF) in apical periodontitis (AP) patients. Methodology Two hundred and sixty one healthy subjects (HS) and 158 patients with AP classified as: 46 ac...

Full description

Saved in:
Bibliographic Details
Published in:International endodontic journal 2023-04, Vol.56 (4), p.419-431
Main Authors: Cruz, Alvaro, Gascón, Luis Gerardo, Palafox‐Sánchez, Claudia Azucena, Flores‐García, Christian, Espinoza‐García, Noemí, Sagrero‐Fabela, Nefertari, Cintra, Luciano Tavares Angelo, Mejía‐Flores, Rocío, Salazar‐Camarena, Diana Celeste
Format: Article
Language:English
Subjects:
acute apical abscess
Alleles
apical periodontitis
B-Cell Activating Factor - genetics
Blood cells
BLyS protein
Case-Control Studies
Gene Frequency
Gene polymorphism
Genetic Predisposition to Disease
Genotype
Gum disease
Humans
Interleukin-4 - genetics
Periapical Periodontitis - genetics
Periodontitis
Peripheral blood
Polymerase chain reaction
Polymorphism
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
rs9514828
sBAFF
Serum levels
TNFSF13B polymorphisms
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim The aim of this case‐control study was to evaluate the association between the TNFSF13B rs9514828 (−871 C > T) polymorphism and soluble BAFF (sBAFF) in apical periodontitis (AP) patients. Methodology Two hundred and sixty one healthy subjects (HS) and 158 patients with AP classified as: 46 acute apical abscess (AAA), 81 primary AP (pAP) and 31 secondary AP (sAP) patients were included. Genomic DNA (gDNA) was extracted from peripheral blood cells according to the salting out method. The TNFSF13B rs9514828 (NC_000013.11:g.108269025C > T) were identified using polymerase chain reaction (PCR) followed by restriction fragment length polymorphisms (RFLP). Serum sBAFF levels were measured by ELISA test. The chi‐squared or Fisher's exact test was performed. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated to evaluate the risk of AP associated with the rs9514828. The Mann–Whitney U test and Kruskal–Wallis analysis were used for non‐normally distributed data. Differences were considered significant with a p‐value
ISSN:0143-2885
1365-2591
DOI:10.1111/iej.13879