Cerebrospinal Fluid and Plasma Amine Profiles in Interictal Migraine

Objective Impaired amine metabolism has been associated with the etiology of migraine, that is, why patients continue to get migraine attacks. However, evidence from cerebrospinal fluid (CSF) is lacking. Here, we evaluated individual amine levels, global amine profiles, and amine pathways in CSF and...

Full description

Saved in:
Bibliographic Details
Published in:Annals of neurology 2023-04, Vol.93 (4), p.715-728
Main Authors: Onderwater, Gerrit L. J., Dongen, Robin M., Harms, Amy C., Zielman, Ronald, Oosterhout, Willebrordus P. J., Klinken, Jan B., Goeman, Jelle J., Terwindt, Gisela M., Maagdenberg, Arn M. J. M., Hankemeier, Thomas, Ferrari, Michel D.
Format: Article
Language:English
Subjects:
Amines
Arginine
Cerebrospinal fluid
Epilepsy
Etiology
Headache
Humans
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Metabolism
Migraine
Migraine Disorders
Migraine with Aura
Multivariate analysis
Nitric oxide
Phenylalanine
Plasma
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective Impaired amine metabolism has been associated with the etiology of migraine, that is, why patients continue to get migraine attacks. However, evidence from cerebrospinal fluid (CSF) is lacking. Here, we evaluated individual amine levels, global amine profiles, and amine pathways in CSF and plasma of interictal migraine patients and healthy controls. Methods CSF and plasma were sampled between 8:30 am and 1:00 pm, randomly and interchangeably over the time span to avoid any diurnal and seasonal influences, from healthy volunteers and interictal migraine patients, matched for age, sex, and sampling time. The study was approved by the local medical ethics committee. Individual amines (n = 31), global amine profiles, and specific amine pathways were analyzed using a validated ultraperformance liquid chromatography mass spectrometry platform. Results We analyzed n = 99 participants with migraine with aura, n = 98 with migraine without aura, and n = 96 healthy volunteers. Univariate analysis with Bonferroni correction indicated that CSF L‐arginine was reduced in migraine with aura (10.4%, p 
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.26576