Dressing to prevent surgical site infection in adult patients with cancer: a systematic review with meta-analysis

  Purpose To identify the most effective dressing for application to surgical wounds with primary closure to prevent surgical site infection (SSI) in adult patients with cancer undergoing elective surgeries. Methods This systematic review was based on the Preferred Reporting Items for Systematic Rev...

Full description

Saved in:
Bibliographic Details
Published in:Supportive care in cancer 2023-01, Vol.31 (1), p.11-11, Article 11
Main Authors: Dias, Thais Almeida, Fernandes, Daiane Rubinato, dos Santos, Bruna Nogueira, dos Reis, Paula Elaine Diniz, Margatho, Amanda Salles, Silveira, Renata Cristina de Campos Pereira
Format: Article
Language:English
Subjects:
Analysis
Cancer
Cancer patients
Cancer surgery
Clinical trials
Database searching
Disease prevention
Health aspects
Infection
Infection control
Internet/Web search services
Medical dressings
Medicine
Medicine & Public Health
Meta-analysis
Mupirocin
Nursing
Nursing Research
Oncology
Online databases
Online searching
Pain Medicine
Prevention
Rehabilitation Medicine
Review
Surgery
Surgical site infections
Systematic review
Wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:  Purpose To identify the most effective dressing for application to surgical wounds with primary closure to prevent surgical site infection (SSI) in adult patients with cancer undergoing elective surgeries. Methods This systematic review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis , with online searches conducted in the CINHAL, Cochrane Central, LILACS, PubMed, Scopus, Embase, Livivo, and Web of Science databases. An additional search was conducted in gray literature using Google Scholar. The risk of bias was assessed using RoB 2.0. The certainty of evidence was evaluated using the Grading of Recommendations Assessment and Development and Evaluation , and the results were synthesized in a descriptive manner and using meta-analysis. Results Eleven randomized clinical trials were conducted to compare different types of dressing—silver dressing with absorbent dressing ( n  = 3), mupirocin dressing with paraffin/no dressing ( n  = 1), honey-based dressing with absorbent dressing ( n  = 1), vitamin E and silicone-containing dressing with absorbent dressing ( n  = 1), and negative pressure wound therapy with absorbent dressing ( n  = 4)—and compare the usage duration of absorbent dressing ( n  = 1). Nine trials presented a low risk of bias, and two were classified as having uncertain bias. Compared with absorbent dressing, silver dressing did not reduce the risk of developing any type of SSI in 894 clinical trial participants (risk relative RR: 0.72; 95% confidence interval [CI] [0.44, 1.17] p  = 0.18). Compared with absorbent dressing, negative pressure wound therapy did not reduce the risk of developing any type of SSI in the 1041 participants of two clinical trials (RR 0.68; 95% CI [0.31, 1.26] p  = 0.22). The certainty of evidence of the three meta-analyses was considered low or very low for the prevention of SSI. We believe that this low certainty of evidence can be improved by conducting new studies in the future. Conclusion There is no evidence regarding which dressing is the most effective in preventing SSI in adult patients with cancer.
ISSN:0941-4355
1433-7339
DOI:10.1007/s00520-022-07467-8