Independent euglycaemic hyperinsulinaemic clamp studies validate clinically applicable formulae to estimate insulin sensitivity in people with type 1 diabetes

• Published in: Diabetes & metabolic syndrome clinical research & reviews 2023-01, Vol.17 (1), p.102691-102691, Article 102691
• Main Authors: Januszewski, Andrzej S., Niedzwiecki, Pawel, Sachithanandan, Nirupa, Ward, Glenn M., Karschimkus, Connie S., O'Neal, David N., Zozulinska-Ziolkiewicz, Dorota A., Uruska, Aleksandra A., Jenkins, Alicia J.
• Format: Article
• Language: English
• Subjects: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Glucose; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance
• ISSN: 1871-4021; 1878-0334
• DOI: 10.1016/j.dsx.2022.102691

Low insulin sensitivity (IS) increases Type 1 diabetes (T1D) complication risk and can be estimated by simple formulae developed from complex euglycemic hyperinsulinaemic clamp studies. We aimed to validate these formulae using independent clamp data. Clamps were performed in 104 T1D adults. Measured glucose disposal rate (GDR) was correlated with eGDR and eLog10 M/I calculated by five IS formulae. Correlations ranged between 0.23–0.40. Two IS formulae (by the authors), using age, sex, HDL-C, HbA1c, pulse pressure, BMI, and waist-hip-ratio had the highest correlation with measured GDR and the best performance in detecting low IS. •Insulin resistance in people with Type 1 diabetes is associated with adverse outcomes.•Clinically applicable means to estimate and monitor insulin sensitivity (IS) are desirable.•IS estimates derived from clamp studies should be validated in independent clamp series.•We validate five formulae to estimate IS in independent (n=104) clamp study series.•Two of the authors IS formulae had the highest correlation with clamp-measured IS.