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Cellular retinol-binding protein 1: a therapeutic and diagnostic tumor marker
Cellular Retinol Binding Protein 1 ( CRBP1 ) gene is a protein coding gene located on human chromosome 3q21, which codifies a protein named CRBP1. CRBP1 is widely expressed in many tissues as a chaperone protein to regulate the uptake, subsequent esterification and bioavailability of retinol. CRBP1...
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| Published in: | Molecular biology reports 2023-02, Vol.50 (2), p.1885-1894 |
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| Main Authors: | , , , , , , , |
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| container_end_page | 1894 |
| container_issue | 2 |
| container_start_page | 1885 |
| container_title | Molecular biology reports |
| container_volume | 50 |
| creator | Guo, Zhiyuan Zhao, Yinshen Wu, Yuqi Zhang, Yuqi Wang, Ruoyan Liu, Wan Zhang, Chaoyang Yang, Xianguang |
| description | Cellular Retinol Binding Protein 1 (
CRBP1
) gene is a protein coding gene located on human chromosome 3q21, which codifies a protein named CRBP1. CRBP1 is widely expressed in many tissues as a chaperone protein to regulate the uptake, subsequent esterification and bioavailability of retinol. CRBP1 combines retinol and retinaldehyde with high affinity to protect retinoids from non-specific oxidation, and transports retinoids to specific enzymes to promote the biosynthesis of retinoic acid. The vital role of CRBP1 in retinoids metabolism has been gradually discovered, which has been implicated in tumorigenesis. However, the precise functions of CRBP1 in different diseases are still poorly understood. The purpose of this review is to provide an overview of the role of CRBP1 in various diseases, especially in both the promotion and inhibition of cancers, which may also offer a novel biomarker and potential therapeutic target for human diseases. |
| doi_str_mv | 10.1007/s11033-022-08179-2 |
| format | article |
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CRBP1
) gene is a protein coding gene located on human chromosome 3q21, which codifies a protein named CRBP1. CRBP1 is widely expressed in many tissues as a chaperone protein to regulate the uptake, subsequent esterification and bioavailability of retinol. CRBP1 combines retinol and retinaldehyde with high affinity to protect retinoids from non-specific oxidation, and transports retinoids to specific enzymes to promote the biosynthesis of retinoic acid. The vital role of CRBP1 in retinoids metabolism has been gradually discovered, which has been implicated in tumorigenesis. However, the precise functions of CRBP1 in different diseases are still poorly understood. The purpose of this review is to provide an overview of the role of CRBP1 in various diseases, especially in both the promotion and inhibition of cancers, which may also offer a novel biomarker and potential therapeutic target for human diseases.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-022-08179-2</identifier><identifier>PMID: 36515825</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animal Anatomy ; Animal Biochemistry ; Apoptosis ; Bioavailability ; Biological activity ; Biomarkers ; Biomarkers, Tumor - genetics ; Biomedical and Life Sciences ; Cancer therapies ; Catalysis ; Chromosome 3 ; Colorectal cancer ; Dehydrogenases ; DNA methylation ; Esterification ; Gastric cancer ; Gene expression ; Histology ; Homeostasis ; Humans ; Life Sciences ; Liver cancer ; Metabolism ; Metabolites ; Molecular biology ; Morphology ; Neoplasms - diagnosis ; Neoplasms - genetics ; Neoplasms - therapy ; Pancreatic cancer ; Photoreceptors ; Physiology ; Proteins ; Radiation ; Retinaldehyde ; Retinoic acid ; Retinoids ; Retinoids - metabolism ; Retinol-binding protein ; Retinol-binding protein 1 ; Retinol-Binding Proteins, Cellular - genetics ; Retinol-Binding Proteins, Cellular - metabolism ; Review ; Therapeutic targets ; Tretinoin ; Tumor markers ; Tumorigenesis ; Vitamin A ; Vitamin A - metabolism</subject><ispartof>Molecular biology reports, 2023-02, Vol.50 (2), p.1885-1894</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer Nature B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-d22fda0b14ef809b57466a27b0fae771c328ebce211aa1f55c3b566e7706006e3</cites><orcidid>0000-0002-7617-2816</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36515825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Zhiyuan</creatorcontrib><creatorcontrib>Zhao, Yinshen</creatorcontrib><creatorcontrib>Wu, Yuqi</creatorcontrib><creatorcontrib>Zhang, Yuqi</creatorcontrib><creatorcontrib>Wang, Ruoyan</creatorcontrib><creatorcontrib>Liu, Wan</creatorcontrib><creatorcontrib>Zhang, Chaoyang</creatorcontrib><creatorcontrib>Yang, Xianguang</creatorcontrib><title>Cellular retinol-binding protein 1: a therapeutic and diagnostic tumor marker</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>Cellular Retinol Binding Protein 1 (
CRBP1
) gene is a protein coding gene located on human chromosome 3q21, which codifies a protein named CRBP1. CRBP1 is widely expressed in many tissues as a chaperone protein to regulate the uptake, subsequent esterification and bioavailability of retinol. CRBP1 combines retinol and retinaldehyde with high affinity to protect retinoids from non-specific oxidation, and transports retinoids to specific enzymes to promote the biosynthesis of retinoic acid. The vital role of CRBP1 in retinoids metabolism has been gradually discovered, which has been implicated in tumorigenesis. However, the precise functions of CRBP1 in different diseases are still poorly understood. The purpose of this review is to provide an overview of the role of CRBP1 in various diseases, especially in both the promotion and inhibition of cancers, which may also offer a novel biomarker and potential therapeutic target for human diseases.</description><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Apoptosis</subject><subject>Bioavailability</subject><subject>Biological activity</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomedical and Life Sciences</subject><subject>Cancer therapies</subject><subject>Catalysis</subject><subject>Chromosome 3</subject><subject>Colorectal cancer</subject><subject>Dehydrogenases</subject><subject>DNA methylation</subject><subject>Esterification</subject><subject>Gastric cancer</subject><subject>Gene expression</subject><subject>Histology</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Liver cancer</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Molecular biology</subject><subject>Morphology</subject><subject>Neoplasms - 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Academic</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Zhiyuan</au><au>Zhao, Yinshen</au><au>Wu, Yuqi</au><au>Zhang, Yuqi</au><au>Wang, Ruoyan</au><au>Liu, Wan</au><au>Zhang, Chaoyang</au><au>Yang, Xianguang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cellular retinol-binding protein 1: a therapeutic and diagnostic tumor marker</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2023-02-01</date><risdate>2023</risdate><volume>50</volume><issue>2</issue><spage>1885</spage><epage>1894</epage><pages>1885-1894</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>Cellular Retinol Binding Protein 1 (
CRBP1
) gene is a protein coding gene located on human chromosome 3q21, which codifies a protein named CRBP1. CRBP1 is widely expressed in many tissues as a chaperone protein to regulate the uptake, subsequent esterification and bioavailability of retinol. CRBP1 combines retinol and retinaldehyde with high affinity to protect retinoids from non-specific oxidation, and transports retinoids to specific enzymes to promote the biosynthesis of retinoic acid. The vital role of CRBP1 in retinoids metabolism has been gradually discovered, which has been implicated in tumorigenesis. However, the precise functions of CRBP1 in different diseases are still poorly understood. The purpose of this review is to provide an overview of the role of CRBP1 in various diseases, especially in both the promotion and inhibition of cancers, which may also offer a novel biomarker and potential therapeutic target for human diseases.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>36515825</pmid><doi>10.1007/s11033-022-08179-2</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-7617-2816</orcidid></addata></record> |
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| subjects | Animal Anatomy Animal Biochemistry Apoptosis Bioavailability Biological activity Biomarkers Biomarkers, Tumor - genetics Biomedical and Life Sciences Cancer therapies Catalysis Chromosome 3 Colorectal cancer Dehydrogenases DNA methylation Esterification Gastric cancer Gene expression Histology Homeostasis Humans Life Sciences Liver cancer Metabolism Metabolites Molecular biology Morphology Neoplasms - diagnosis Neoplasms - genetics Neoplasms - therapy Pancreatic cancer Photoreceptors Physiology Proteins Radiation Retinaldehyde Retinoic acid Retinoids Retinoids - metabolism Retinol-binding protein Retinol-binding protein 1 Retinol-Binding Proteins, Cellular - genetics Retinol-Binding Proteins, Cellular - metabolism Review Therapeutic targets Tretinoin Tumor markers Tumorigenesis Vitamin A Vitamin A - metabolism |
| title | Cellular retinol-binding protein 1: a therapeutic and diagnostic tumor marker |
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