Function without feeling: neural reactivity and intercommunication during flexible motor adjustments evoked by emotional and neutral stimuli

Abstract Motor conflicts arise when we need to quickly overwrite prepotent behavior. It has been proposed that affective stimuli modulate the neural processing of motor conflicts. However, previous studies have come to inconsistent conclusions regarding the neural impact of affective information on...

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Published in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2023-05, Vol.33 (10), p.6000-6012
Main Authors: Kaiser, Jakob, Gentsch, Antje, Rodriguez-Manrique, Daniela, Schütz-Bosbach, Simone
Format: Article
Language:English
Subjects:
Brain - physiology
Brain Mapping
Emotions - physiology
Gyrus Cinguli - diagnostic imaging
Gyrus Cinguli - physiology
Insular Cortex
Magnetic Resonance Imaging
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Summary:Abstract Motor conflicts arise when we need to quickly overwrite prepotent behavior. It has been proposed that affective stimuli modulate the neural processing of motor conflicts. However, previous studies have come to inconsistent conclusions regarding the neural impact of affective information on conflict processing. We employed functional magnetic resonance imaging during a Go/Change-Go task, where motor conflicts were either evoked by neutral or emotionally negative stimuli. Dynamic causal modeling was used to investigate how motor conflicts modulate the intercommunication between the anterior cingulate cortex (ACC) and the anterior insula (AI) as 2 central regions for cognitive control. Conflicts compared to standard actions were associated with increased BOLD activation in several brain areas, including the dorsal ACC and anterior insula. There were no differences in neural activity between emotional and non-emotional conflict stimuli. Conflicts compared to standard actions lowered neural self-inhibition of the ACC and AI and led to increased effective connectivity from the ACC to AI contralateral to the acting hand. Thus, our study indicates that neural conflict processing is primarily driven by the functional relevance of action-related stimuli, not their inherent affective meaning. Furthermore, it sheds light on the role of interconnectivity between ACC and AI for the implementation of flexible behavioral change.
ISSN:1047-3211
1460-2199
DOI:10.1093/cercor/bhac478