The effects of peracetic acid solution on the treatment of otomycosis in an animal model: a new antifungal drug?

• Published in: Journal of laryngology and otology 2023-07, Vol.137 (7), p.799-803
• Main Authors: Nemati, S, Akbarpour, M, Lotfali, E, Nosrati, R, Rafiee, E, Zebardast, N
• Format: Article
• Language: English
• Subjects: Acetic acid; Acids; Animal models; Animals; Antifungal agents; Antifungal Agents - therapeutic use; Antimicrobial agents; Aspergillosis - drug therapy; Aspergillosis - microbiology; Aspergillus niger; Bacterial infections; Drug resistance; Ear canal; Eardrum; Ears & hearing; Edema; Fungal infections; Guinea Pigs; Inflammation; Main Article; Otomycosis; Otomycosis - drug therapy; Otomycosis - microbiology; Oxidation; Peracetic acid; Peracetic Acid - pharmacology; Peracetic Acid - therapeutic use; Thermometers; Tympanic membrane
• ISSN: 0022-2151; 1748-5460
• DOI: 10.1017/S002221512200264X

This study aimed to investigate the therapeutic effects of 1 per cent and 0.01 per cent peracetic acid as an antifungal agent in animal otomycosis. After creating a superficial scratch in the external auditory canal of guinea pigs, a suspension of , and candida were inoculated into the ears of the animals. After otomycosis, the effect of 1 per cent or 0.01 per cent peracetic acid on otomycosis was evaluated by otomicroscopy and culture at 10 days post-treatment and compared with 2 per cent acetic acid as the control. A 10-day treatment with 1 per cent peracetic acid and 2 per cent acetic acid (control) showed normal otomicroscopy and negative cultures compared with 0.01 per cent peracetic acid. Drug sedimentation or other side effects in the external auditory canal or tympanic membrane were not observed during treatment with peracetic acid. The findings of this study confirm that the treatment of otomycosis with 1 per cent peracetic acid in an animal model is beneficial and may be a novel therapeutic treatment for otomycosis.