Recent Trends in Diagnostic Biomarkers of Tumor Microenvironment

The tumor microenvironment (TME) play critical roles in tumor survival, progression, and metastasis and can be considered potential targets for molecular imaging of cancer. The targeting agents for imaging of TME components ( e.g. , fibroblasts, mesenchymal stromal cells, immune cells, extracellular...

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Bibliographic Details
Published in:Molecular imaging and biology 2023-06, Vol.25 (3), p.464-482
Main Authors: Siminzar, Paniz, Tohidkia, Mohammad Reza, Eppard, Elisabeth, Vahidfar, Nasim, Tarighatnia, Ali, Aghanejad, Ayuob
Format: Article
Language:English
Subjects:
Biomarkers
Blood vessels
Cancer
Extracellular matrix
Fibroblasts
Humans
Imaging
Immune system
Medical diagnosis
Medical imaging
Medicine
Medicine & Public Health
Mesenchymal Stem Cells - pathology
Metastases
Molecular Imaging
Neoplasms - diagnosis
Neoplasms - pathology
Radiology
Review Article
Stromal cells
Tumor Microenvironment
Tumors
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Summary:The tumor microenvironment (TME) play critical roles in tumor survival, progression, and metastasis and can be considered potential targets for molecular imaging of cancer. The targeting agents for imaging of TME components ( e.g. , fibroblasts, mesenchymal stromal cells, immune cells, extracellular matrix, blood vessels) provide a promising strategy to target these biomarkers for the early diagnosis of cancers. Moreover, various cancer types have similar tumor immune microenvironment (TIME) features that targeting those biomarkers and offer clinically translatable molecular imaging of cancers. In this review, we categorize and summarize the components in TME which have been targeted for molecular imaging. Moreover, this review updated the recent progress in targeted imaging of TIME biological molecules by various modalities for the early detection of cancer. Graphical Abstract
ISSN:1536-1632
1860-2002
DOI:10.1007/s11307-022-01795-1