A variant rs6214 within IGF-1 confers risk for ulcerative colitis in Chinese Han populations

Insulin growth factor-1 (IGF-1) has been found to correlate with various diseases such as cancer and cardiovascular diseases including ulcerative colitis (UC). The present study aimed to investigate the plausible association of rs6214 (C > T) within IGF-1 and UC susceptibility in Chinese Han popu...

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Bibliographic Details
Published in:Functional & integrative genomics 2023-03, Vol.23 (1), p.1-1, Article 1
Main Authors: Wang, Huiping, Wang, Jin, Geng, Chunsong, Wang, Cong, Gu, Rongrong, Zhu, Zhansheng
Format: Article
Language:English
Subjects:
Alleles
Animal Genetics and Genomics
Biochemistry
Bioinformatics
Biomedical and Life Sciences
Cardiovascular diseases
Case-Control Studies
Cell Biology
Colitis, Ulcerative - genetics
East Asian People - genetics
Fibrinogen - genetics
Gene Frequency
Genetic analysis
Genetic Predisposition to Disease - genetics
Genotype
Genotypes
Humans
Inflammatory bowel disease
Insulin
Insulin - genetics
Insulin-like growth factor I
Insulin-Like Growth Factor I - genetics
Life Sciences
Microbial Genetics and Genomics
MicroRNAs
mRNA
Original Article
Plant Genetics and Genomics
Polymorphism, Single Nucleotide
Risk
Ulcerative colitis
Variance analysis
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Summary:Insulin growth factor-1 (IGF-1) has been found to correlate with various diseases such as cancer and cardiovascular diseases including ulcerative colitis (UC). The present study aimed to investigate the plausible association of rs6214 (C > T) within IGF-1 and UC susceptibility in Chinese Han populations. A total of 977 UC patients and 1029 healthy controls were enrolled, and rs6214 was genotyped with PCR and direct sequencing on the ABI 3730XL DNA analyzer platform. Logistic regression analysis was applied for the correlation of rs6214 and UC susceptibility via calculation of odds ratio (OR) with a 95% confidence interval (95% CI) adjusted for age and sex under different genetic models. The difference of clinical parameters between genotypes was measured by one-way analysis of variance (ANOVA). Additional functional assays were conducted to establish the probable relationship. The results indicated that the T allele of rs6214 showed roughly 37% greater risk for UC risk in the additive model ( OR  = 1.37, 95% CI = 1.21–1.55, P  
ISSN:1438-793X
1438-7948
DOI:10.1007/s10142-022-00921-0