Getting to the root of Ralstonia invasion

• Published in: Seminars in cell & developmental biology 2023-10, Vol.148-149, p.3-12
• Main Authors: Rivera-Zuluaga, Katherine, Hiles, Rachel, Barua, Pragya, Caldwell, Denise, Iyer-Pascuzzi, Anjali S.
• Format: Article
• Language: English
• Subjects: Plant Diseases - microbiology; Plant pathogenic bacteria; Plants; Ralstonia; Ralstonia solanacearum - genetics; Root disease; Virulence
• ISSN: 1084-9521; 1096-3634
• DOI: 10.1016/j.semcdb.2022.12.002

Plant diseases caused by soilborne pathogens are a major limiting factor in crop production. Bacterial wilt disease, caused by soilborne bacteria in the Ralstonia solanacearum Species Complex (Ralstonia), results in significant crop loss throughout the world. Ralstonia invades root systems and colonizes plant xylem, changing plant physiology and ultimately causing plant wilting in susceptible varieties. Elucidating how Ralstonia invades and colonizes plants is central to developing strategies for crop protection. Here we review Ralstonia pathogenesis from root detection and attachment, early root colonization, xylem invasion and subsequent wilting. We focus primarily on studies in tomato from the last 5–10 years. Recent work has identified elegant mechanisms Ralstonia uses to adapt to the plant xylem, and has discovered new genes that function in Ralstonia fitness in planta. A picture is emerging of an amazingly versatile pathogen that uses multiple strategies to make its surrounding environment more hospitable and can adapt to new environments.