Long‐term outcomes of kidney transplantation from deceased donors with terminal acute kidney injury: Single center experience and literature review

• Published in: Clinical transplantation 2023-03, Vol.37 (3), p.e14886-n/a
• Main Authors: Garner, Matthew, Jay, Colleen L., Sharda, Berjesh, Webb, Christopher, Farney, Alan C., Orlando, Giuseppe, Rogers, Jeffrey, Reeves‐Daniel, Amber, Mena‐Gutierrez, Alejandra, Sakhovskaya, Natalia, Stratta, Bobby, Stratta, Robert J.
• Format: Article
• Language: English
• Subjects: Acute Kidney Injury; Adult; Brain Death; deceased donor; delayed graft function; Delayed Graft Function - etiology; Graft Survival; Humans; Kidney; Kidney Transplantation - adverse effects; outcomes; Retrospective Studies; standard criteria donors; Tissue Donors
• ISSN: 0902-0063; 1399-0012
• DOI: 10.1111/ctr.14886

Introduction Long‐term outcomes of kidney transplantation from deceased donors (DDKTs) with terminal acute kidney injury (AKI) are not well defined. Methods Single center retrospective review of DDKTs from 1/31/07‐12/31/19. AKI kidneys were defined by a doubling of the donor's admission serum creatinine (SCr) level AND a terminal SCr ≥2.0 mg/dl. Results A total of 188 AKI DDKTs were performed, including 154 from brain‐dead standard criteria donors (SCD). Mean donor age was 36 years and mean Kidney Donor Profile Index was 50%; mean admission and terminal SCr levels were 1.3 and 3.1 mg/dl, respectively. With a mean follow‐up of 94 months (median 89 months), overall patient (both 71.3%) and graft survival (54% AKI vs. 57% non‐AKI) rates were comparable to concurrent DDKTs from brain‐dead non‐AKI SCDs (n = 769). Delayed graft function (DGF) was higher in AKI kidney recipients (47% vs. 20% non‐AKI DDKTs, p