Development and validation of neoadjuvant rectal score-based signature nomograms to predict overall survival and disease-free survival in locally advanced rectal cancer: a retrospective, double center, cohort study

Aim To evaluate the prognostic significance of the NAR score and develop nomograms for locally advanced rectal cancer (LARC) treated after neoadjuvant chemo-radiotherapy (nCRT) combined with total meso-rectal excision (TME) surgery to predict prognostic. Methods Retrospective collection among LARC p...

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Published in:International journal of clinical oncology 2023-02, Vol.28 (2), p.268-279
Main Authors: Wang, Guancong, Tang, Zihan, Ye, Jiahong, Tang, Haiwen, Yao, Kaiyuan, Zeng, Qunzhang, Yang, Yugang, Fu, Muhai, Luo, Lixiong, Shen, Qiyuan, Fang, Xun, Ling, Bijuan, Fang, Yicong, Guo, Yincong, Huang, Ying
Format: Article
Language:English
Subjects:
Cancer Research
Cohort Studies
Colorectal cancer
Disease-Free Survival
Humans
Medicine
Medicine & Public Health
Metastases
Metastasis
Neoadjuvant Therapy
Nomograms
Oncology
Original Article
Patients
Prognosis
Radiation therapy
Rectal Neoplasms - pathology
Rectum
Retrospective Studies
Surgery
Surgical Oncology
Survival
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Summary:Aim To evaluate the prognostic significance of the NAR score and develop nomograms for locally advanced rectal cancer (LARC) treated after neoadjuvant chemo-radiotherapy (nCRT) combined with total meso-rectal excision (TME) surgery to predict prognostic. Methods Retrospective collection among LARC patients treated at Fujian Medical University Union Hospital (training cohort) and Fujian Medical University Affiliated Zhangzhou Hospital (external validation cohort) between Jan 10, 2011 and Dec 28, 2021. The NAR score was calculated by formula: [5pN-3(cT-pT) + 12]^2/9.61. NAR score low ( 16). Results 1665 patients in the training cohort and 256 patients in the external validation cohorts were enrolled. Lower NAR score was significantly associated with better cumulative incidence of OS, DFS, local recurrence (LR), and distant metastasis (DM) (all P  
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-022-02281-y