Energy Balance and Bone Health: a Nutrient Availability Perspective

Purpose of Review Obesity is highly prevalent and is associated with bone fragility and fracture. The changing nutrient availability to bone in obesity is an important facet of bone health. The goal of this article is to summarize current knowledge on the effects of carbohydrate and dietary fat avai...

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Bibliographic Details
Published in:Current osteoporosis reports 2023-02, Vol.21 (1), p.77-84
Main Authors: Bermudez, Beatriz, Ishii, Toru, Wu, Yuan-Haw, Carpenter, R. Dana, Sherk, Vanessa D.
Format: Article
Language:English
Subjects:
Bone Density
Dietary Fats - metabolism
Energy Intake
Energy Metabolism
Epidemiology
Exercise
Exercise and Lifestyle (S Shapses and R Daly
Humans
Lifestyle in Osteoporosis
Medicine
Medicine & Public Health
Nutrients
Nutrition
Obesity - metabolism
Orthopedics
Section Editors
Topical Collection on Nutrition
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Summary:Purpose of Review Obesity is highly prevalent and is associated with bone fragility and fracture. The changing nutrient availability to bone in obesity is an important facet of bone health. The goal of this article is to summarize current knowledge on the effects of carbohydrate and dietary fat availability on bone, particularly in the context of other tissues. Recent Findings The skeleton is a primary site for fatty acid and glucose uptake. The trafficking of carbohydrates and fats into tissues changes with weight loss and periods of weight gain. Exercise acutely influences nutrient uptake into bone and may affect nutrient partitioning to bone. Bone cells secrete hormones that signal to the brain and other tissues information about its energetic state, which may alter whole-body nutrient trafficking. Summary There is a critical need for studies to address the changes that metabolic perturbations have on nutrient availability in bone.
ISSN:1544-1873
1544-2241
DOI:10.1007/s11914-022-00765-4