The diagnostic role of pathergy test in patients with Behçet’s disease from the Western Europe

The aim of the study is to evaluate the frequency and features of positive pathergy test (PPT) in Italy, its role in the diagnosis of Behçet’s disease (BD), and any association with other BD-related manifestations. 52 BD patients, 52 patients with axial spondyloarthritis (ax-SpA), and 26 healthy con...

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Published in:Internal and emergency medicine 2023, Vol.18 (1), p.77-83
Main Authors: Vitale, Antonio, Berlengiero, Virginia, Caggiano, Valeria, Barneschi, Sara, Mourabi, Mariam, Sota, Jurgen, Gentileschi, Stefano, Maggio, Maria Cristina, Gaggiano, Carla, Tarsia, Maria, Tosi, Gian Marco, Lopalco, Giuseppe, Fabiani, Claudia, Frediani, Bruno, Cantarini, Luca
Format: Article
Language:English
Subjects:
Arthritis
Behcet disease
Behcet Syndrome - complications
Behcet Syndrome - diagnosis
Behcet's syndrome
Diagnosis
Erythema
Europe
Humans
Im - Original
Immune system
Inflammatory diseases
Innate immunity
Internal Medicine
Italy
Medical diagnosis
Medicine
Medicine & Public Health
Rheumatic diseases
Saliva
Sensitivity analysis
Sensitivity and Specificity
Skin tests
Skin Tests - methods
Statistical analysis
Vein & artery diseases
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Summary:The aim of the study is to evaluate the frequency and features of positive pathergy test (PPT) in Italy, its role in the diagnosis of Behçet’s disease (BD), and any association with other BD-related manifestations. 52 BD patients, 52 patients with axial spondyloarthritis (ax-SpA), and 26 healthy controls (HCs) underwent intradermal injection of normal saline and intradermal needle soaked with fresh self-saliva. The results of pathergy tests were statistically analysed in the light of demographic, clinical, and therapeutic features of subjects enrolled. Pathergy test performed with saline resulted always negative in all groups. Skin prick test using self-saliva resulted in the occurrence of a papule in 3 (5.8%) BD patients and in 1 (1.9%) patient with ax-SpA. A ≥ 15 mm erythematous area surrounding the needle prick site was observed in 22 (42.3%) BD patients, 5 (9.6%) patients with ax-SpA, and 2 (7.7%) HCs ( p  = 0.00002). The frequency of skin erythema was significantly more frequent in patients with BD than those with ax-SpA ( p  
ISSN:1828-0447
1970-9366
DOI:10.1007/s11739-022-03117-3