Ethnic/racial differences in risk factors and clinical outcomes among patients with amyloidosis

Cardiac amyloidosis is caused by abnormal extracellular deposition of insoluble fibrils in cardiac tissue. It can be fatal when untreated and is often underdiagnosed. Understanding the ethnic/racial differences in risk factors is critical for early diagnosis and treatment to improve clinical outcome...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of the medical sciences 2023-03, Vol.365 (3), p.232-241
Main Authors: Ream, Sarah, Ma, Jennifer, Rodriguez, Tayana, Sarabia-Gonzalez, Alejandro, Alvarado, Luis A., Dwivedi, Alok Kumar, Mukherjee, Debabrata
Format: Article
Language:English
Subjects:
Aged
Amyloidosis
Amyloidosis, Racial differences
Cardiac amyloidosis
Cross-Sectional Studies
Gastrointestinal bleeding
Heart failure
Humans
Male
Race Factors
Renal failure
Renal Insufficiency
Retrospective Studies
Risk Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cardiac amyloidosis is caused by abnormal extracellular deposition of insoluble fibrils in cardiac tissue. It can be fatal when untreated and is often underdiagnosed. Understanding the ethnic/racial differences in risk factors is critical for early diagnosis and treatment to improve clinical outcomes. We performed a retrospective cross-sectional study utilizing the National Inpatient Sample database from 2015 to 2018 using ICD-10-CM codes. The primary variables of interest were race/ethnicity and amyloidosis subtypes, while the primary outcomes were in-hospital mortality, gastrointestinal bleeding, renal failure, and hospital length-of-stay. Amyloidosis was reported in 0.17% of all hospitalizations (N  =  19,678,415). Of these, 0.09% were non-Hispanic whites, 0.04% were non-Hispanic blacks, and 0.02% were Hispanic. Hospitalizations with ATTR amyloidosis subtype were frequently observed in older individuals and males with coronary artery disease, whereas AL amyloidosis subtype was associated with non-Hispanic whites, congestive heart failure, and longer hospital length of stay. Renal failure was associated with non-Hispanic blacks (adjusted relative risk [RR]  =  1.31, p 
ISSN:0002-9629
1538-2990
DOI:10.1016/j.amjms.2022.12.009