MRI characteristics for predicting histological subtypes in patients with uterine cervical adenocarcinoma

•HPVIs and GASs tend to show heterogeneous enhancement.•HPVIs have a larger tumor size compared to HPVAs.•GASs show infiltrative growth pattern with intratumoral cysts compared to non-GASs. To evaluate the magnetic resonance imaging (MRI) findings of uterine cervical adenocarcinoma for predicting di...

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Bibliographic Details
Published in:European journal of radiology 2023-01, Vol.158, p.110612-110612, Article 110612
Main Authors: Mori, Takayuki, Kato, Hiroki, Kawaguchi, Masaya, Kanayama, Tomohiro, Furui, Tatsuro, Noda, Yoshifumi, Hyodo, Fuminori, Matsuo, Masayuki
Format: Article
Language:English
Subjects:
Adenocarcinoma - pathology
Cervical adenocarcinoma
Cervical cancer
Cysts
Female
Gastric type
HPV
Humans
Magnetic Resonance Imaging
MRI
Papillomavirus Infections - pathology
Retrospective Studies
Stomach Neoplasms
Uterine Cervical Neoplasms - diagnostic imaging
Uterine Cervical Neoplasms - pathology
Uterine Neoplasms
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Summary:•HPVIs and GASs tend to show heterogeneous enhancement.•HPVIs have a larger tumor size compared to HPVAs.•GASs show infiltrative growth pattern with intratumoral cysts compared to non-GASs. To evaluate the magnetic resonance imaging (MRI) findings of uterine cervical adenocarcinoma for predicting different histological subtypes. We retrospectively analyzed MRI findings of 76 consecutive patients with histopathologically-confirmed uterine cervical adenocarcinoma undergoing preoperative MRI examination. An experienced pathologist classified the histological subtypes based on World Health Organization’s 2020 classification and into human papillomavirus (HPV)-associated adenocarcinomas (HPVAs, n = 54) (usual type and variants) and HPV-independent adenocarcinomas (HPVIs, n = 22) (gastric type adenocarcinoma (GAS), clear cell type, and other types). Different MRI variables were compared quantitatively and qualitatively between HPVA and HPVI and between GAS and non-GAS tumor types. The maximum tumor diameter was significantly greater in HPVIs than HPVAs (41.9 ± 18.6 vs 32.7 ± 15.6 mm; p 
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2022.110612