Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide‐treated mice

• Published in: Journal of the science of food and agriculture 2023-04, Vol.103 (6), p.3050-3064
• Main Authors: Tian, Baoming, Liu, Renjian, Xu, Tianrui, Cai, Ming, Mao, Rongliang, Huang, Liangshui, Yang, Kai, Zeng, Xiaoxiong, Peilong, Sun
• Format: Article
• Language: English
• Subjects: Animals; Bacteria; Basidiomycota - chemistry; Body weight; Community structure; Cyclophosphamide; Digestive system; Fatty acids; Fatty Acids, Volatile; Gastrointestinal Microbiome; Gastrointestinal tract; gut microbiota; Hericium erinaceus; Hericium erinaceus polysaccharides; Immune response; immune responses; Immune system; Immunity; Immunodeficiency; Immunoregulation; Immunosuppression; intestinal immune function; Intestinal microflora; Mice; Microbiota; mRNA; NF-kappa B; Polysaccharides; Polysaccharides - chemistry; Proteins; Ruminococcaceae; Saccharides; short‐chain fatty acids; Taxonomy; TLR4 protein; Toll-Like Receptor 4; Toll-like receptors
• ISSN: 0022-5142; 1097-0010
• DOI: 10.1002/jsfa.12404

BACKGROUND The gut microbiota (GM) is recognized as a significant contributor to the immune system. In the present study, the effects of Hericium erinaceus polysaccharides (HEP) on immunoregulation and GM in cyclophosphamide (CTX)‐treated mice were investigated to elucidate the attenuate of immunosuppression by modulating GM. RESULTS The results revealed that HEP significantly improved the body weight and immune organ index in immunodeficient mice (P