The varied spectrum of nephroblastomatosis, nephrogenic rests, and Wilms tumors: Review of current definitions and challenges of the field

The diagnosis of multiple or diffuse renal lesions in a child is challenging by imaging and/or pathology. Optimal management requires distinguishing benign lesions such as nephrogenic rests from cancerous lesions such as Wilms tumor, but this is often difficult or impossible. This difficulty is comp...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric blood & cancer 2023-05, Vol.70 (S2), p.e30162-n/a
Main Authors: Fialkowski, Elizabeth, Sudour‐Bonnange, Hélène, Vujanic, Gordan M., Shamberger, Robert C., Chowdhury, Tanzina, Aldrink, Jennifer H., Davick, Jonathan, Sandberg, Jesse, Furtwaengler, Rhoikos, Mullen, Elizabeth
Format: Article
Language:English
Subjects:
Child
Diagnosis
Diagnostic Imaging
Hematology
Humans
Kidney - pathology
Kidney Neoplasms - pathology
Kidneys
Lesions
nephroblastomatosis
nephrogenic rests
Oncology
Pediatrics
Rest
Tumors
Wilms Tumor - pathology
Wilms tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The diagnosis of multiple or diffuse renal lesions in a child is challenging by imaging and/or pathology. Optimal management requires distinguishing benign lesions such as nephrogenic rests from cancerous lesions such as Wilms tumor, but this is often difficult or impossible. This difficulty is compounded by the overlapping nature of our current radiologic and pathologic definitions of lesions along the spectrum of nephrogenic rests/nephroblastomatosis. We provide a review of these issues, as a collaborative effort between the Children's Oncology Group Renal Tumor Committee and International Society of Pediatric Oncology Renal Tumor Study Group. Our aim is to discuss current challenges in diagnosis and management of these renal lesions, encouraging future work toward consensus definitions for research and patient care.
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.30162