Citric acid esterified Glutinous Assam bora rice starch enhances disintegration and dissolution efficiency of model drug

• Published in: International journal of biological macromolecules 2023-02, Vol.227, p.424-436
• Main Authors: Kalita, Pratap, Ahmed, Abdul Baquee, Sen, Saikat, Chakraborty, Raja
• Format: Article
• Language: English
• Subjects: Assam bora rice starch; Citrated starch; Citric Acid; Disintegration efficiency; Dissolution efficiency; Oryza - chemistry; Packing and rearrangement behaviour; Physicochemical attributes; Solubility; Starch - chemistry; Tablets - chemistry
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2022.12.149

The current work was designed to study the starch's physicochemical attributes, tablet disintegration and dissolution efficiency and its derivatives obtained from the glutinous Assam bora rice (G-ABR) variety of Assam, Northeast India. Starch was isolated by a simple protein denaturation method, and a starch derivative was prepared through citric acid modification. G-ABRS and citrated G-ABRS were characterized through FTIR, DSC, XRD and SEM. The rate of consolidation, consolidation index, angle of internal friction, packing rearrangement and cohesive properties were determined to investigate their applications as functional excipients in pharmaceutical industries. G-ABRS and citrated G-ABRS exhibited better packing rearrangement and cohesive properties than standard corn starch. Furthermore, immediate release of API from the tablet compact was observed when the starch concentration increased from 1 to 5 %, indicating facilitation of the tablet compact disintegration. Therefore, G-ABRS and citrated G-ABRS are potentially functional and sustainable materials for pharmaceutical industries. [Display omitted] •Novel starch was isolated and modified to obtain functional starch.•G-ABRS and citrated G-ABRS characterized through FTIR, DSC, SEM and XRD.•Both starches showed better packing rearrangement and cohesive attributes.•Tableting properties were evaluated for prepared tablets.•Prepared tablets exhibited significant disintegration and dissolution efficiency.