Mechanisms of radioresistance and the underlying signaling pathways in colorectal cancer cells

Radiotherapy is one of the most common modalities for the treatment of a wide range of tumors, including colorectal cancer (CRC); however, radioresistance of cancer cells remains a major limitation for this treatment. Following radiotherapy, the activities of various cellular mechanisms and cell sig...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cellular biochemistry 2023-01, Vol.124 (1), p.31-45
Main Authors: Tessmann, Josiane W., Rocha, Murilo R., Morgado‐Díaz, Jose A.
Format: Article
Language:English
Subjects:
autophagy
Cancer
cancer stem cells
Cell Line, Tumor
Cell signaling
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - metabolism
epithelial–mesenchymal transition
Humans
In vivo methods and tests
Medical prognosis
polyploid giant cancer cells
Radiation therapy
Radiation Tolerance
Radioresistance
Side effects
Signal Transduction
Signaling
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Radiotherapy is one of the most common modalities for the treatment of a wide range of tumors, including colorectal cancer (CRC); however, radioresistance of cancer cells remains a major limitation for this treatment. Following radiotherapy, the activities of various cellular mechanisms and cell signaling pathways are altered, resulting in the development of radioresistance, which leads to therapeutic failure and poor prognosis in patients with cancer. Furthermore, even though several inhibitors have been developed to target tumor resistance, these molecules can induce side effects in nontumor cells due to low specificity and efficiency. However, the role of these mechanisms in CRC has not been extensively studied. This review discusses recent studies regarding the relationship between radioresistance and the alterations in a series of cellular mechanisms and cell signaling pathways that lead to therapeutic failure and tumor recurrence. Our review also presents recent advances in the in vitro/in vivo study models aimed at investigating the radioresistance mechanism in CRC. Furthermore, it provides a relevant biochemical basis in theory, which can be useful to improve radiotherapy sensitivity and prolong patient survival.
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.30361