The effects of sugammadex vs. neostigmine on postoperative respiratory complications and advanced healthcare utilisation: a multicentre retrospective cohort study

Reversing neuromuscular blockade with sugammadex can eliminate residual paralysis, which has been associated with postoperative respiratory complications. There are equivocal data on whether sugammadex reduces these when compared with neostigmine. We investigated the association of the choice of rev...

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Bibliographic Details
Published in:Anaesthesia 2023-03, Vol.78 (3), p.294-302
Main Authors: Suleiman, A, Munoz-Acuna, R, Azimaraghi, O, Houle, T T, Chen, G, Rupp, S, Witt, A S, Azizi, B A, Ahrens, E, Shay, D, Wongtangman, K, Wachtendorf, L J, Tartler, T M, Eikermann, M, Schaefer, M S
Format: Article
Language:English
Subjects:
Adult
Airway management
Anesthesia
Cholinesterase Inhibitors - adverse effects
Clinical outcomes
Cohort analysis
Complications
Equivalence
General anesthesia
Health care
Health services utilization
Humans
Intubation
Mechanical ventilation
Neostigmine
Neostigmine - adverse effects
Neuromuscular Blockade - adverse effects
Oxygen content
Paralysis
Patient Acceptance of Health Care
Patients
Postoperative Complications - chemically induced
Postoperative Complications - epidemiology
Postoperative Complications - prevention & control
Postoperative period
Respiration
Respiration Disorders - chemically induced
Respiratory failure
Retrospective Studies
Sugammadex - adverse effects
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Summary:Reversing neuromuscular blockade with sugammadex can eliminate residual paralysis, which has been associated with postoperative respiratory complications. There are equivocal data on whether sugammadex reduces these when compared with neostigmine. We investigated the association of the choice of reversal drug with postoperative respiratory complications and advanced healthcare utilisation. We included adult patients who underwent surgery and received general anaesthesia with sugammadex or neostigmine reversal at two academic healthcare networks between January 2016 and June 2021. The primary outcome was postoperative respiratory complications, defined as post-extubation oxygen saturation
ISSN:0003-2409
1365-2044
DOI:10.1111/anae.15940