Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic methods

Infertility is experienced by 8 % -12 % of adults in their reproductive period globally and has become a prevalent concern. Besides routine therapeutic methods, stem cells are rapidly being examined as viable alternative therapies in regenerative medicine and translational investigation. Remarkable...

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Bibliographic Details
Published in:Frontiers of medicine 2022-12, Vol.16 (6), p.827-858
Main Authors: Babaei, Kosar, Aziminezhad, Mohsen, Norollahi, Seyedeh Elham, Vahidi, Sogand, Samadani, Ali Akbar
Format: Article
Language:English
Subjects:
Adipocytes
Alternative medicine
Cell Differentiation
Cell- and Tissue-Based Therapy
Humans
Infertility
Infertility - therapy
Medicine
Medicine & Public Health
Mesenchymal Stem Cell Transplantation - methods
mesenchymal stem cells
pluripotent stem cells
Regenerative Medicine
Reproductive health
Review
stem cell therapy
Stem cells
Umbilical Cord
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Summary:Infertility is experienced by 8 % -12 % of adults in their reproductive period globally and has become a prevalent concern. Besides routine therapeutic methods, stem cells are rapidly being examined as viable alternative therapies in regenerative medicine and translational investigation. Remarkable progress has been made in understanding the biology and purpose of stem cells. The affected pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) are further studied for their possible use in reproductive medicine, particularly for infertility induced by premature ovarian insufficiency and azoospermia. Accordingly, this study discusses current developments in the use of some kinds of MSCs such as adipose-derived stem cells, bone marrow stromal cells, umbilical cord MSCs, and menstrual blood MSCs. These methods have been used to manage ovarian and uterine disorders, and each technique presents a novel method for the therapy of infertility.
ISSN:2095-0217
2095-0225
DOI:10.1007/s11684-022-0948-8