Establishment of measles virus receptor‐expressing Vero cells lacking functional poliovirus receptors

Global efforts are underway to eliminate measles and rubella, and active viral surveillance is the key to achieving this goal. In addition, the World Health Organization announced guidelines for handling materials potentially infectious for poliovirus (PV) to minimize the risk of PV reintroduction a...

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Bibliographic Details
Published in:Microbiology and immunology 2023-03, Vol.67 (3), p.166-170
Main Authors: Someya, Kenji, Okemoto‐Nakamura, Yuko, Kurata, Takako, Kanbayashi, Daiki, Saito, Noriko, Itamochi, Masae, Otsuki, Noriyuki, Hanada, Kentaro, Takeda, Makoto
Format: Article
Language:English
Subjects:
Animals
Cell lines
Chlorocebus aethiops
Humans
Measles - epidemiology
Measles virus
Poliovirus
receptor
Receptors, Virus - genetics
Rubella
Rubella virus
SLAM
Vero Cells
Viruses
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Summary:Global efforts are underway to eliminate measles and rubella, and active viral surveillance is the key to achieving this goal. In addition, the World Health Organization announced guidelines for handling materials potentially infectious for poliovirus (PV) to minimize the risk of PV reintroduction and to achieve PV eradication. To support global efforts, we established new PV‐non‐susceptible cell lines that are useful for the isolation of measles virus (MeV) and rubella virus (RuV) (Vero ΔPVR1/2 hSLAM+). In the cell lines, MeV and RuV replicated efficiently, with no concern regarding PV replication.
ISSN:0385-5600
1348-0421
DOI:10.1111/1348-0421.13047