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Establishment of measles virus receptor‐expressing Vero cells lacking functional poliovirus receptors

Global efforts are underway to eliminate measles and rubella, and active viral surveillance is the key to achieving this goal. In addition, the World Health Organization announced guidelines for handling materials potentially infectious for poliovirus (PV) to minimize the risk of PV reintroduction a...

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Published in:Microbiology and immunology 2023-03, Vol.67 (3), p.166-170
Main Authors: Someya, Kenji, Okemoto‐Nakamura, Yuko, Kurata, Takako, Kanbayashi, Daiki, Saito, Noriko, Itamochi, Masae, Otsuki, Noriyuki, Hanada, Kentaro, Takeda, Makoto
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container_end_page 170
container_issue 3
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container_title Microbiology and immunology
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creator Someya, Kenji
Okemoto‐Nakamura, Yuko
Kurata, Takako
Kanbayashi, Daiki
Saito, Noriko
Itamochi, Masae
Otsuki, Noriyuki
Hanada, Kentaro
Takeda, Makoto
description Global efforts are underway to eliminate measles and rubella, and active viral surveillance is the key to achieving this goal. In addition, the World Health Organization announced guidelines for handling materials potentially infectious for poliovirus (PV) to minimize the risk of PV reintroduction and to achieve PV eradication. To support global efforts, we established new PV‐non‐susceptible cell lines that are useful for the isolation of measles virus (MeV) and rubella virus (RuV) (Vero ΔPVR1/2 hSLAM+). In the cell lines, MeV and RuV replicated efficiently, with no concern regarding PV replication.
doi_str_mv 10.1111/1348-0421.13047
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ispartof Microbiology and immunology, 2023-03, Vol.67 (3), p.166-170
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source Wiley; Alma/SFX Local Collection
subjects Animals
Cell lines
Chlorocebus aethiops
Humans
Measles - epidemiology
Measles virus
Poliovirus
receptor
Receptors, Virus - genetics
Rubella
Rubella virus
SLAM
Vero Cells
Viruses
title Establishment of measles virus receptor‐expressing Vero cells lacking functional poliovirus receptors
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