Can the triglyceride-glucose index predict insulin resistance in LGA newborns?

Background The aim of this study is to investigate the TyG index and TG/HDL-C ratio and their relationships with insulin resistance in LGA infants. Methods A prospective controlled study was conducted including 65 LGA and gestational age, gender-matched appropriate for gestational age (AGA) neonates...

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Published in:Journal of perinatology 2023-09, Vol.43 (9), p.1119-1124
Main Authors: Kavurt, Sumru, Uzlu, Safiye Elif, Bas, Ahmet Yagmur, Tosun, Mehtap, Çelen, Şevki, Üstün, Yaprak Engin, Demirel, Nihal
Format: Article
Language:English
Subjects:
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Cholesterol
Gestational age
Glucose
High density lipoprotein
Insulin
Insulin resistance
Medicine
Medicine & Public Health
Neonates
Newborn babies
Pediatric Surgery
Pediatrics
Triglycerides
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Summary:Background The aim of this study is to investigate the TyG index and TG/HDL-C ratio and their relationships with insulin resistance in LGA infants. Methods A prospective controlled study was conducted including 65 LGA and gestational age, gender-matched appropriate for gestational age (AGA) neonates. Serum TG, total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), insulin and glucose levels were measured within two hours after birth, TyG index and HOMA-IR values were calculated. Results TyG index and TG/HDL- C ratio were higher in LGA neonates compared to AGA ones ( p  = 0.03; p  = 0.00, respectively). Compared with AGA newborns, LGA newborns had higher levels of insulin and HOMA-IR ( p  = 0.00; p  = 0.00, respectively). TyG index and TG/HDL-C ratio showed moderate correlation with HOMA-IR ( r  = 0.59 R 2  = 0.35 p  
ISSN:0743-8346
1476-5543
DOI:10.1038/s41372-022-01586-0